冈比亚锥虫与小鼠白细胞在体内的相互作用。

In vivo interaction between Trypanosoma gambiense and leucocytes in mice.

作者信息

Takahashi Y, Miyamoto H, Fukuma T, Nishiyama T, Araki T, Shinka S

机构信息

Department of Parasitology, Nara Medical University, Japan.

出版信息

Zentralbl Bakteriol Mikrobiol Hyg A. 1987 May;264(3-4):399-406. doi: 10.1016/s0176-6724(87)80062-7.

DOI:10.1016/s0176-6724(87)80062-7

PMID:3660979

Abstract

Naturally occurring phagocytosis of Trypanosoma gambiense by mouse eosinophils and neutrophils was reported. In vivo and in vitro experiments using monoclonal antibodies confirmed that the phagocytosis is triggered by G1 class antibodies against variable surface antigen. Ultrastructural observation revealed the mode of entry and the intracellular fate of T. gambiense: initial attachment, pseudopodia formation and complete invagination. This phagocytosis resulted in the killing of T. gambiense by mouse eosinophils and neutrophils, suggesting that eosinophils and neutrophils give at least partial protection against infection with T. gambiense in combination with the specific antibodies.

摘要

据报道，小鼠嗜酸性粒细胞和中性粒细胞可对冈比亚锥虫进行天然吞噬作用。使用单克隆抗体进行的体内和体外实验证实，这种吞噬作用是由针对可变表面抗原的G1类抗体触发的。超微结构观察揭示了冈比亚锥虫的进入方式和细胞内命运：最初附着、伪足形成和完全内陷。这种吞噬作用导致小鼠嗜酸性粒细胞和中性粒细胞杀死冈比亚锥虫，这表明嗜酸性粒细胞和中性粒细胞与特异性抗体结合至少能提供部分针对冈比亚锥虫感染的保护作用。