Thattai Mukund
Simons Centre for the Study of Living Machines, National Centre for Biological Sciences, TIFR, Bangalore, India.
Curr Opin Cell Biol. 2023 Feb;80:102151. doi: 10.1016/j.ceb.2022.102151. Epub 2023 Jan 5.
In eukaryotic cells, the budding and fusion of intracellular transport vesicles is carefully orchestrated in space and time. Locally, a vesicle's source compartment, its cargo, and its destination compartment are controlled by dynamic multi-protein specificity modules. Globally, vesicle constituents must be recycled to ensure homeostasis of compartment compositions. The emergence of a novel vesicle pathway therefore requires new specificity modules as well as new recycling routes. Here, we review recent research on local (molecular) constraints on gene module duplication and global (cellular) constraints on intracellular recycling. By studying the evolution of vesicle traffic, we may discover general principles of how complex traits arise via multiple intermediate steps.
在真核细胞中，细胞内运输小泡的出芽和融合在空间和时间上都受到精心调控。在局部，小泡的来源区室、其货物以及目的地区室由动态的多蛋白特异性模块控制。在整体上，小泡成分必须进行循环利用以确保区室组成的稳态。因此，一种新的小泡运输途径的出现需要新的特异性模块以及新的循环途径。在这里，我们综述了关于基因模块复制的局部（分子）限制和细胞内循环利用的整体（细胞）限制的近期研究。通过研究小泡运输的进化，我们可能会发现复杂性状如何通过多个中间步骤产生的一般原理。
