O'Rahilly R, Müller F, Hutchins G M, Moore G W
Carnegie Laboratories of Embryology, California Primate Research Center, University of California, Davis 95616.
Am J Anat. 1987 Sep;180(1):69-86. doi: 10.1002/aja.1001800106.
The sequence of events in the development of the brain in human embryos, already published for stages 8-15, is here continued for stages 16 and 17. With the aid of a computerized bubble-sort algorithm, 71 individual embryos were ranked in ascending order of the features present. Whereas these numbered 100 in the previous study, the increasing structural complexity gave 27 new features in the two stages now under investigation. The chief characteristics of stage 16 (approximately 37 postovulatory days) are protruding basal nuclei, the caudal olfactory elevation (olfactory tubercle), the tectobulbar tracts, and ascending fibers to the cerebellum. The main features of stage 17 (approximately 41 postovulatory days) are the cortical nucleus of the amygdaloid body, an intermediate layer in the tectum mesencephali, the posterior commissure, and the habenulo-interpeduncular tract. In addition, a typical feature at stage 17 is the crescentic shape of the lens cavity.
人类胚胎大脑发育过程中的事件序列，已发表了8 - 15阶段的内容，本文继续介绍16和17阶段。借助计算机化的冒泡排序算法，71个个体胚胎按照所呈现特征的升序排列。在前一项研究中这些特征有100个，而随着结构复杂性的增加，在目前研究的这两个阶段出现了27个新特征。16阶段（约排卵后37天）的主要特征是基底核突出、尾侧嗅觉隆起（嗅结节）、顶盖延髓束以及向小脑的上行纤维。17阶段（约排卵后41天）的主要特征是杏仁体的皮质核、中脑顶盖的中间层、后连合以及缰核脚间束。此外，17阶段的一个典型特征是晶状体腔呈新月形。
