Department of Oriental Pharmacy and Wonkwang-Oriental Medicines Research Institute, Wonkwang University, Iksan 570-749, Republic of Korea.
Department of Pharmacy, Crimson College of Technology, Pokhara University, Devinagar-11, Butwal 32900, Nepal.
Molecules. 2022 Dec 28;28(1):255. doi: 10.3390/molecules28010255.
Ponciri Fructus is a crude drug obtained from the dried immature fruits of (L). Raf. (Syn. L.). This study aims to compile and analyze the ethnomedicinal uses, bioactive constituents, and pharmacological activities of Ponciri Fructus. Various online bibliographic databases namely, SciFinder, PubMed, Google Scholar, and Web of Science were used for collecting information on traditional uses, biological activities, and bioactive constituents. Concerning ethnomedicinal uses, Ponciri Fructus is extensively used in traditional Korean, Chinese, and Kampo medicines to mitigate allergic reactions, inflammation, edema, digestive complications, respiratory problems, spleen-related problems, liver complications, neuronal pain, hyperlipidemia, rheumatoid arthritis, cardiovascular problems, hernia, sinusitis, and insomnia. Several studies have shown that Ponciri Fructus is a major source of diverse classes of bioactive compounds namely flavonoids, terpenoids, coumarins, phytosterols, and alkaloids. Several in vivo and in vitro pharmacological activity evaluations such as antidiabetic, anti-obesity, anti-inflammatory, antiallergic, antimelanogenic, gastroprotective, anticancer, and neuroprotective effects have been conducted from Ponciri Fructus. However, scientific investigations focusing on bioassay-guided isolation and identification of specific bioactive constituents are limited. Therefore, an in-depth scientific investigation of Ponciri Fructus focusing on bioassay-guided isolation, mechanism based pharmacological studies, pharmacokinetic studies, and evaluation of possible toxicities is necessary in the future.
枳实为芸香科酸橙及其栽培变种或甜橙的干燥未成熟果实。本研究旨在汇编和分析枳实的民间用途、生物活性成分和药理学活性。通过使用 SciFinder、PubMed、Google Scholar 和 Web of Science 等各种在线文献数据库，收集了有关传统用途、生物活性和生物活性成分的信息。在民间用途方面，枳实广泛应用于传统的韩国、中国和汉方药中，以减轻过敏反应、炎症、水肿、消化并发症、呼吸问题、脾脏问题、肝脏并发症、神经痛、高血脂、类风湿性关节炎、心血管问题、疝气、鼻窦炎和失眠。多项研究表明，枳实是多种生物活性化合物的主要来源，包括类黄酮、萜类、香豆素、植物甾醇和生物碱。已对枳实进行了多项体内和体外药理学活性评估，如抗糖尿病、抗肥胖、抗炎、抗过敏、抗黑色素生成、胃保护、抗癌和神经保护作用。然而，针对生物活性成分的基于生物测定的分离和鉴定的科学研究还很有限。因此，未来有必要对枳实进行深入的科学研究，包括基于生物测定的分离、基于机制的药理学研究、药代动力学研究以及对可能毒性的评估。
