Research Progress of HS Donors Conjugate Drugs Based on ADTOH.

HS is an endogenous gas signaling molecule and its multiple biological effects have been demonstrated. The abnormal level of HS is closely related to the occurrence and development of many diseases, and HS donors has important pharmacological implications. In recent years, HS donors represented by ADTOH (5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thione) are often used to synthesize new 'conjugate' compounds that can release HS and parent drugs. These hybrids retain the pharmacological activity of the parent drugs and HS and have a synergistic effect. ADTOH and parent drug hybrids have become one of the important strategies for the development of HS donor conjugate drugs. This review summarizes molecular hybrids between ADTOH and clinical drugs to provide new ideas for the study of HS donor drug design.