Ben-Shahar M, Rosenblatt E, Green J, Cohen I
Department of Oncology, Rambam Medical Center, Bat-Galim, Haifa, Israel.
Am J Med Sci. 1987 Oct;294(4):262-7. doi: 10.1097/00000441-198710000-00009.
A 65-year-old man manifested certain features of scleroderma several years before discovery of malignant thymoma. Following tumor resection, the signs and symptoms of scleroderma did not improve, and the patient experienced the abrupt onset of renal failure with malignant hypertension 7 months after the operation. The scleroderma renal crisis caused terminal renal failure, which was treated by chronic hemodialysis. This is the second reported case of thymoma associated with progressive systemic sclerosis (PSS). The authors suggest that thymoma and various immunologic disorders have a common etiologic factor which has not yet been found. This case emphasizes that thymectomy frequently has little effect on the course of the immunologic disease. The implications of the association of thymoma and PSS are discussed.
一名65岁男性在发现恶性胸腺瘤数年前就出现了硬皮病的某些特征。肿瘤切除后，硬皮病的体征和症状并未改善，且患者在术后7个月突然出现肾衰竭并伴有恶性高血压。硬皮病肾危象导致终末期肾衰竭，通过慢性血液透析进行治疗。这是第二例报道的与进行性系统性硬化症（PSS）相关的胸腺瘤病例。作者认为胸腺瘤和各种免疫性疾病有一个尚未被发现的共同病因。该病例强调胸腺切除术对免疫性疾病的病程通常影响不大。文中讨论了胸腺瘤与PSS关联的意义。
