HLA - G在哮喘中的作用及其作为有效治疗剂的潜力。

HLA-G in asthma and its potential as an effective therapeutic agent.

作者信息

Li Jinyan, Hao Yuqiu, Li Wei, Lv Xuejiao, Gao Peng

机构信息

Jilin University Second Hospital, Changchun City, Jilin Province, China.

Jilin University Second Hospital, Changchun City, Jilin Province, China;

出版信息

Allergol Immunopathol (Madr). 2023 Jan 1;51(1):22-29. doi: 10.15586/aei.v51i1.650. eCollection 2023.

DOI:10.15586/aei.v51i1.650

PMID:36617818

Abstract

OBJECTIVE

Asthma is a heterogeneous disease. Severity of asthma and sensitivity to medications vary across asthma subtypes. Human leukocyte antigen (HLA)-G has a wide range of functions in normal and pathological physiology. Due to its powerful immune function, HLA-G participates in the pathogenesis of different asthma phenotypes by regulating the activity and function of various immune cells. The mechanism of HLA-G in asthma is not fully clear, and there is no consensus on its mechanism in asthma. Further studies are needed to explore the role of HLA-G in different phenotypes of human asthma.

METHODS

Observational study.

RESULTS

HLA-G is an important immunomodulatory factor in asthma. Studies have found different levels of HLA-G in patients with different asthma subtypes and healthy controls, but other studies have come to the opposite conclusion.

CONCLUSION

We speculate that further study on the mechanism of HLA-G in asthma pheno-types may explain some of the contradictions in current studies. Findings should provide information regarding the potential of HLA-G as a novel target for asthma diagnosis and treatment.

摘要

目的

哮喘是一种异质性疾病。哮喘的严重程度和对药物的敏感性在不同哮喘亚型中有所不同。人类白细胞抗原（HLA）-G在正常和病理生理学中具有广泛的功能。由于其强大的免疫功能，HLA-G通过调节各种免疫细胞的活性和功能参与不同哮喘表型的发病机制。HLA-G在哮喘中的机制尚不完全清楚，其在哮喘中的作用机制也未达成共识。需要进一步研究以探索HLA-G在人类哮喘不同表型中的作用。