Li Jinyan, Hao Yuqiu, Li Wei, Lv Xuejiao, Gao Peng
Jilin University Second Hospital, Changchun City, Jilin Province, China.
Jilin University Second Hospital, Changchun City, Jilin Province, China;
Allergol Immunopathol (Madr). 2023 Jan 1;51(1):22-29. doi: 10.15586/aei.v51i1.650. eCollection 2023.
Asthma is a heterogeneous disease. Severity of asthma and sensitivity to medications vary across asthma subtypes. Human leukocyte antigen (HLA)-G has a wide range of functions in normal and pathological physiology. Due to its powerful immune function, HLA-G participates in the pathogenesis of different asthma phenotypes by regulating the activity and function of various immune cells. The mechanism of HLA-G in asthma is not fully clear, and there is no consensus on its mechanism in asthma. Further studies are needed to explore the role of HLA-G in different phenotypes of human asthma.
Observational study.
HLA-G is an important immunomodulatory factor in asthma. Studies have found different levels of HLA-G in patients with different asthma subtypes and healthy controls, but other studies have come to the opposite conclusion.
We speculate that further study on the mechanism of HLA-G in asthma pheno-types may explain some of the contradictions in current studies. Findings should provide information regarding the potential of HLA-G as a novel target for asthma diagnosis and treatment.
哮喘是一种异质性疾病。哮喘的严重程度和对药物的敏感性在不同哮喘亚型中有所不同。人类白细胞抗原（HLA）-G在正常和病理生理学中具有广泛的功能。由于其强大的免疫功能，HLA-G通过调节各种免疫细胞的活性和功能参与不同哮喘表型的发病机制。HLA-G在哮喘中的机制尚不完全清楚，其在哮喘中的作用机制也未达成共识。需要进一步研究以探索HLA-G在人类哮喘不同表型中的作用。
观察性研究。
HLA-G是哮喘中的一种重要免疫调节因子。研究发现不同哮喘亚型患者和健康对照中HLA-G水平不同，但其他研究得出了相反的结论。
我们推测，进一步研究HLA-G在哮喘表型中的机制可能解释当前研究中的一些矛盾之处。研究结果应提供有关HLA-G作为哮喘诊断和治疗新靶点潜力的信息。
