Li Na, Liu Yulei
Department of Dermatology, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region, China.
Department of Dermatology, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region, China;
Allergol Immunopathol (Madr). 2023 Jan 1;51(1):140-145. doi: 10.15586/aei.v51i1.765. eCollection 2023.
To unravel the role of La ribonucleoprotein 7 (LARP7), a transcriptional regulator, in the progression of psoriasis and the underlying molecular mechanisms.
The psoriasis-like mice model was created by daily administering of imiquimod on shaved skin. The histological analysis and skin damage were evaluated in each group. The inflammation and oxidative stress response were assessed by enzyme-linked-immunosorbent serologic and immunoblot assays. The involvement of silent information regulator 1 (member of the Sirtuin family; SIRT1/nuclear factor kappa B (NF-κB) signaling pathway in LARP7-mediated psoriasis progression was also detected by immunoblot assay.
LARP7 relieved psoriasis symptoms in the mice model. LARP7 inhibited the expression of inflammatory cytokines as well as chemokines in psoriasis-like skin tissues. Additionally, LARP7 suppressed oxidative stress in the psoriasis-like skin tissues of mice. LARP7 inhibited the activation of the SIRT1/NF-κB signaling pathway, and therefore affected the progression of psoriasis.
LARP7 relieved psoriasis symptoms in mice by regulating the SIRT1/NF-κB signaling pathway.
揭示转录调节因子La核糖核蛋白7（LARP7）在银屑病进展中的作用及其潜在分子机制。
通过每日在剃毛皮肤上涂抹咪喹莫特建立银屑病样小鼠模型。对每组进行组织学分析和皮肤损伤评估。通过酶联免疫吸附血清学和免疫印迹分析评估炎症和氧化应激反应。还通过免疫印迹分析检测沉默信息调节因子1（沉默调节蛋白家族成员；SIRT1）/核因子κB（NF-κB）信号通路在LARP7介导的银屑病进展中的参与情况。
LARP7缓解了小鼠模型中的银屑病症状。LARP7抑制了银屑病样皮肤组织中炎性细胞因子以及趋化因子的表达。此外，LARP7抑制了小鼠银屑病样皮肤组织中的氧化应激。LARP7抑制了SIRT1/NF-κB信号通路的激活，从而影响了银屑病的进展。
LARP7通过调节SIRT1/NF-κB信号通路缓解了小鼠的银屑病症状。
