Lyu Jie, Cai Huajing, Chen Yeru, Chen Gang
Department of Anesthesiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Front Integr Neurosci. 2022 Dec 21;16:1031613. doi: 10.3389/fnint.2022.1031613. eCollection 2022.
Sevoflurane is presently one of the most used inhaled anesthetics worldwide. However, the mechanisms through which sevoflurane acts and the areas of the brain associated with changes in consciousness during anesthesia remain important and complex research questions. Sevoflurane is generally regarded as a volatile anesthetic that blindly targets neuronal (and sometimes astrocyte) GABAA receptors. This review focuses on the brain areas of sevoflurane action and their relation to changes in consciousness during anesthesia. We cover 20 years of history, from the bench to the bedside, and include perspectives on functional magnetic resonance, electroencephalogram, and pharmacological experiments. We review the interactions and neurotransmitters involved in brain circuits during sevoflurane anesthesia, improving the effectiveness and accuracy of sevoflurane's future application and shedding light on the mechanisms behind human consciousness.
七氟醚是目前全球使用最广泛的吸入性麻醉剂之一。然而，七氟醚的作用机制以及麻醉期间与意识变化相关的脑区仍然是重要且复杂的研究问题。七氟醚通常被视为一种挥发性麻醉剂，盲目地作用于神经元（有时也作用于星形胶质细胞）的GABAA受体。本综述聚焦于七氟醚的作用脑区及其与麻醉期间意识变化的关系。我们涵盖了从实验室到临床的20年历程，并纳入了功能磁共振成像、脑电图和药理学实验等方面的观点。我们回顾了七氟醚麻醉期间脑回路中涉及的相互作用和神经递质，以提高七氟醚未来应用的有效性和准确性，并阐明人类意识背后的机制。
