NLRP3炎性小体在消化系统恶性肿瘤中的作用。

Sun Cen-Cen, Li Li, Tao Hou-Quan, Jiang Zhi-Chen, Wang Liang, Wang Hui-Ju

Basic Medical Experimental Teaching Center, Zhejiang University, Hangzhou, China.

Key Laboratory of Gastroenterology of Zhejiang Province, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, China.

Front Cell Dev Biol. 2022 Dec 23;10:1051612. doi: 10.3389/fcell.2022.1051612. eCollection 2022.

Digestive system malignancies, the most common types of cancer and a major cause of death in the worldwide, are generally characterized by high morbidity, insidious symptoms and poor prognosis. NLRP3 inflammasome, the most studied inflammasome member, is considered to be crucial in tumorigenesis. In this paper, we reviewed its pro-tumorigenic and anti-tumorigenic properties in different types of digestive system malignancy depending on the types of cells, tissues and organs involved, which would provide promising avenue for exploring new anti-cancer therapies.

消化系统恶性肿瘤是全球最常见的癌症类型和主要死因，其特点通常是发病率高、症状隐匿且预后不良。NLRP3炎性小体是研究最多的炎性小体成员，被认为在肿瘤发生中起关键作用。在本文中，我们根据所涉及的细胞、组织和器官类型，综述了其在不同类型消化系统恶性肿瘤中的促肿瘤和抗肿瘤特性，这将为探索新的抗癌疗法提供有前景的途径。