伴有肾脏损害的家族性桥本甲状腺炎。
Familial Hashimoto's thyroiditis with kidney impairment.
作者信息
Shuper A, Leathem T, Pertzelan A, Eisenstein B, Mimouni M
机构信息
Department of Paediatrics B, Institute of Paediatric Endocrinology, Petah Tikva, Israel.
出版信息
Arch Dis Child. 1987 Aug;62(8):811-4. doi: 10.1136/adc.62.8.811.
A 12 year old boy and his two sisters with Hashimoto's thyroiditis and renal impairment were studied. Three generations of this family had autoimmune thyroid disease: Graves' disease was diagnosed in the first generation, and the second and third generations had thyroid enlargement with abnormal thyroid function and immunological abnormalities. The disease in this family could not be explained simply by the types of human leucocyte antigens found. Renal disease in autoimmune thyroid disease is uncommon, treatment difficult, and the prognosis unknown. The proteinuria disappeared in all three children during the three and a half years of follow up, which implies that the renal impairment may be transitory in some patients.
对一名患有桥本甲状腺炎和肾功能损害的12岁男孩及其两名姐妹进行了研究。这个家族的三代人都患有自身免疫性甲状腺疾病：第一代被诊断为格雷夫斯病，第二代和第三代有甲状腺肿大，甲状腺功能异常和免疫异常。这个家族的疾病不能简单地用所发现的人类白细胞抗原类型来解释。自身免疫性甲状腺疾病中的肾脏疾病并不常见，治疗困难，预后未知。在三年半的随访中，所有三个孩子的蛋白尿都消失了，这意味着在一些患者中肾功能损害可能是暂时的。
Zotero 插件