Department of Operating Room, The Affiliated Nanhua Hospital of South China, Hengyang, China.
Department of Hand Surgery, The Affiliated Nanhua Hospital of South China, Hengyang, China.
Medicine (Baltimore). 2022 Dec 9;101(49):e31984. doi: 10.1097/MD.0000000000031984.
In epidemiological research, the link between coffee consumption and bone mineral density (BMD) is still debated. Moreover, there hasn't been any research on the relationship between urine caffeine and caffeine metabolites and BMD. This study aimed to investigate if there was a connection between urine caffeine and its metabolites and BMD in people between the ages of 8 and 19. Using data from the National Health and Nutrition Examination Survey 2009 to 2014, multivariate logistic regression models were utilized to investigate the association between urinary caffeine and caffeine metabolites and total BMD. Fitted smoothing curves and generalized additive models were also used. A total of 1235 adolescents were included in this analysis, after controlling for various variables, we found that the association between urinary theophylline and total BMD was negative, whereas the association between urinary paraxanthine, theobromine and caffeine and total BMD was positive. In our study, an inverted U-shaped association between urinary paraxanthine and urinary caffeine was found with BMD in women. In this cross-sectional study, the correlation between urinary caffeine and its metabolites and total BMD differed by sex and race. More studies are needed to confirm the results of this study and to investigate the underlying causes.
在流行病学研究中，咖啡摄入与骨密度（BMD）之间的联系仍存在争议。此外，尚未有研究探讨尿咖啡因及其代谢物与 BMD 之间的关系。本研究旨在调查 8 至 19 岁人群的尿咖啡因及其代谢物与 BMD 是否存在关联。利用 2009 年至 2014 年全国健康与营养调查的数据，采用多变量逻辑回归模型来探讨尿咖啡因及其代谢物与总 BMD 之间的关系。还使用了拟合平滑曲线和广义相加模型。在控制了各种变量后，共有 1235 名青少年被纳入本分析。我们发现，尿茶碱与总 BMD 呈负相关，而尿黄嘌呤、可可碱和咖啡因与总 BMD 呈正相关。在本研究中，我们发现女性尿黄嘌呤与尿咖啡因与 BMD 之间呈倒 U 型关联。在这项横断面研究中，尿咖啡因及其代谢物与总 BMD 的相关性因性别和种族而异。需要进一步的研究来证实本研究的结果，并探讨其潜在原因。
