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Targeting protein clearance pathways in -associated Parkinson disease.

作者信息

Chen Chase, Hertz Ellen, Chen Yu, Sidransky Ellen

机构信息

Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.

出版信息

Expert Opin Ther Targets. 2022 Dec;26(12):1031-1035. doi: 10.1080/14728222.2022.2166828. Epub 2023 Jan 12.

Abstract
摘要

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本文引用的文献

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GALC variants affect galactosylceramidase enzymatic activity and risk of Parkinson's disease.
Brain. 2023 May 2;146(5):1859-1872. doi: 10.1093/brain/awac413.
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Mutant glucocerebrosidase impairs α-synuclein degradation by blockade of chaperone-mediated autophagy.
Sci Adv. 2022 Feb 11;8(6):eabm6393. doi: 10.1126/sciadv.abm6393. Epub 2022 Feb 9.
4
PROTAC targeted protein degraders: the past is prologue.
Nat Rev Drug Discov. 2022 Mar;21(3):181-200. doi: 10.1038/s41573-021-00371-6. Epub 2022 Jan 18.
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Targeting of Lysosomal Pathway Genes for Parkinson's Disease Modification: Insights From Cellular and Animal Models.
Front Neurol. 2021 Jun 14;12:681369. doi: 10.3389/fneur.2021.681369. eCollection 2021.
10
PROTAC Compounds Targeting α-Synuclein Protein for Treating Neurogenerative Disorders: Alzheimer's and Parkinson's Diseases.
ACS Med Chem Lett. 2020 Apr 28;11(6):1086-1087. doi: 10.1021/acsmedchemlett.0c00192. eCollection 2020 Jun 11.

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