Tenchov Rumiana, Sasso Janet M, Zhou Qiongqiong Angela
CAS, a division of the American Chemical Society, Columbus, Ohio 43210, United States.
ACS Omega. 2025 Jan 8;10(2):1864-1892. doi: 10.1021/acsomega.4c09114. eCollection 2025 Jan 21.
Parkinson's disease (PD) is a progressive neurodegenerative disorder that primarily affects movement. It occurs due to a gradual deficit of dopamine-producing brain cells, particularly in the substantia nigra. The precise etiology of PD is not fully understood, but it likely involves a combination of genetic and environmental factors. The therapies available at present alleviate symptoms but do not stop the disease's advancement. Research endeavors are currently directed at inventing disease-controlling therapies that aim at the inherent mechanisms of PD. PD biomarker breakthroughs hold enormous potential: earlier diagnosis, better monitoring, and targeted treatment based on individual response could significantly improve patient outcomes and ease the burden of this disease. PD research is an active and evolving field, focusing on understanding disease mechanisms, identifying biomarkers, developing new treatments, and improving care. In this report, we explore data from the CAS Content Collection to outline the research progress in PD. We analyze the publication landscape to offer perspective into the latest expertise advancements. Key emerging concepts are reviewed and strategies to fight disease evaluated. Pharmacological targets, genetic risk factors, as well as comorbid diseases are explored, and clinical usage of products against PD with their production pipelines and trials for drug repurposing are examined. This review aims to offer a comprehensive overview of the advancing landscape of the current understanding about PD, to define challenges, and to assess growth prospects to stimulate efforts in battling the disease.
帕金森病（PD）是一种主要影响运动功能的进行性神经退行性疾病。它的发生是由于产生多巴胺的脑细胞逐渐减少，尤其是在黑质中。PD的确切病因尚未完全明确，但可能涉及遗传和环境因素的综合作用。目前可用的治疗方法可以缓解症状，但无法阻止疾病的进展。目前的研究工作致力于开发针对PD内在机制的疾病控制疗法。PD生物标志物的突破具有巨大潜力：早期诊断、更好的监测以及基于个体反应的靶向治疗可以显著改善患者的预后，并减轻这种疾病的负担。PD研究是一个活跃且不断发展的领域，重点在于理解疾病机制、识别生物标志物、开发新治疗方法以及改善护理。在本报告中，我们从中国知网（CAS）内容数据库中提取数据，以概述PD的研究进展。我们分析文献发表情况，以了解最新的专业进展。对关键的新兴概念进行综述，并评估对抗疾病的策略。探讨药理学靶点、遗传风险因素以及共病，同时研究抗PD产品的临床应用、其生产流程以及药物再利用试验。这篇综述旨在全面概述当前对PD认识的进展情况，明确挑战，并评估发展前景，以推动对抗该疾病的努力。
