Liao Wenlong, Wang Qinghui, Hao Juan, Huang Lijuan, Zheng Li, Yin Zhihang, Chen Yangjie, Zhou Youting, Liu Kunping
Key Laboratory of Coarse Cereal Processing of Ministry of Agriculture and Rural Affair, School of Food and Biological Engineering, Chengdu University, Chengdu, 610106, China.
Key Laboratory of Medicinal and Edible Plants Resources Development of Sichuan Education Department, Sichuan Industrial Institute of Antibiotics, College of Pharmacy, Chengdu University, Chengdu, 610106, China.
Mikrochim Acta. 2023 Jan 11;190(2):50. doi: 10.1007/s00604-023-05631-3.
Poor selectivity and reusability of Au/Ag nanostructures are the main challenges for surface-enhanced Raman spectroscopy (SERS) in real sample detection. Herein, a novel specific and reusable three-dimensional (3D) SERS sensor with dual functions of selective trapping and photocatalytic degradation was designed. Firstly, Au-Ag bimetallic nanoparticles decorated silicon nanowires array (SiNWs-AuAg) were prepared as 3D SERS substrate. Then, silicon-based inorganic-framework molecularly imprinted TiO (TiO@SiMIP) was synthesized and immobilized on SiNWs-AuAg by using rhodamine 6G (R6G) as template molecule. Owing to the excellent SERS performance of SiNWs-AuAg and the specific affinity of TiO@SiMIP to template molecule, the prepared SERS sensor enables sensitive and selective detection of R6G in food samples with a limit of detection (LOD) of 0.27 nM. In addition, due to the photocatalysis of TiO and the stability of silicon-based inorganic framework, the residual templates in TiO@SiMIP can be completely removed by UV irradiation, and the imprinted cavity of regenerated sensors still maintained good selectivity after regeneration by UV irradiation.
金/银纳米结构的选择性差和可重复使用性低是表面增强拉曼光谱（SERS）在实际样品检测中的主要挑战。在此，设计了一种具有选择性捕获和光催化降解双重功能的新型特异性且可重复使用的三维（3D）SERS传感器。首先，制备了装饰有金-银双金属纳米颗粒的硅纳米线阵列（SiNWs-AuAg）作为3D SERS基底。然后，以罗丹明6G（R6G）为模板分子，合成了硅基无机框架分子印迹TiO（TiO@SiMIP）并将其固定在SiNWs-AuAg上。由于SiNWs-AuAg优异的SERS性能以及TiO@SiMIP对模板分子的特异性亲和力，所制备的SERS传感器能够灵敏且选择性地检测食品样品中的R6G，检测限（LOD）为0.27 nM。此外，由于TiO的光催化作用以及硅基无机框架的稳定性，通过紫外线照射可以完全去除TiO@SiMIP中的残留模板，并且再生传感器的印迹腔在紫外线照射再生后仍保持良好的选择性。
