Schumpelik V, Hempel K, Schreiber H W
Langenbecks Arch Chir. 1978 Nov;347:449-56. doi: 10.1007/BF01579375.
Since the first clinical prospective trial of J. Lind in 1753, the controlled study has proved to be an essential instrument in clinical research. Possible topics include: pharmacologic prophylaxis of complications such as stress ulcer, thrombosis, etc., indications for operation, preoperative preparation, choice of surgical procedure, and techniques or postoperative treatment. Examples for each topic are given.