State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, College of Animal Science and Technology, Guangxi University, Nanning, China.
Institute of Reproductive and Developmental Biology, Imperial College London, London, UK.
Wiley Interdiscip Rev RNA. 2023 Jul-Aug;14(4):e1775. doi: 10.1002/wrna.1775. Epub 2023 Jan 11.
Many indicators can be used to evaluate the productivity and quality of livestock, such as meat and milk production as well as fat deposition. Meat and milk production are measures of livestock performance, while fat deposition affects the taste and flavor of the meat. The circRNAs, are non-coding RNAs, that are involved in the regulation of all these three traits. We review the functions and mechanisms of circRNAs in muscle and fat development as well as lactation to provide a theoretical basis for circRNA research in animal husbandry. Various phenotypic changes presented in livestock may be produced by different circRNAs. Our current concern is how to use the roles played by circRNAs to our advantage to produce the best possible livestock. Hence, we describe the advantages and disadvantages of knockout techniques for circRNAs. In addition, we also put forward our thoughts regarding the mechanism and network of circRNAs to provide researchers with novel ideas of how molecular biology can help us advance our goals in animal farming. This article is categorized under: RNA in Disease and Development > RNA in Disease RNA Interactions with Proteins and Other Molecules > Protein-RNA Interactions: Functional Implications RNA Interactions with Proteins and Other Molecules > Protein-RNA Recognition RNA Interactions with Proteins and Other Molecules > RNA-Protein Complexes.
许多指标可用于评估家畜的生产力和质量，例如肉和奶产量以及脂肪沉积。肉和奶产量是家畜性能的衡量标准，而脂肪沉积会影响肉的口感和风味。circRNAs 是一类非编码 RNA，参与调控这三个特征。我们综述了 circRNAs 在肌肉和脂肪发育以及泌乳中的功能和作用机制，为家畜中 circRNA 的研究提供理论依据。家畜中表现出的各种表型变化可能是由不同的 circRNAs 产生的。我们目前关心的是如何利用 circRNAs 发挥的作用使家畜生产达到最佳状态。因此，我们描述了 circRNAs 的敲除技术的优缺点。此外，我们还提出了 circRNAs 的作用机制和网络的相关思考，为研究人员提供了关于分子生物学如何帮助我们实现家畜养殖目标的新想法。本文属于以下分类：RNA 在疾病与发育中的作用 > RNA 在疾病中的作用 RNA 与蛋白质和其他分子的相互作用 > 蛋白-RNA 相互作用：功能意义 RNA 与蛋白质和其他分子的相互作用 > 蛋白-RNA 识别 RNA 与蛋白质和其他分子的相互作用 > RNA-蛋白质复合物。
