Steinbach E, Redianu H
Laryngol Rhinol Otol (Stuttg). 1978 Dec;57(12):1099-109.
Cholesterol granuloma consists of solid metabolic waste products. The essential cause is a closed unaerated space in the middle ear cleft with proliferation of the mucosa, a connective tissue increased production of mucous and their subsequent organisation. During the resorption of this poorly digestable mucous cholesterol crystals are formed which in turn leads to small haemorrhages, increased fibrous tissue formation as well as the accumulation of foreign body giant cells. The analysis of 101 specimens showed different histological forms of cholesterol granuloma due to the different duration of the local pathological process. In the final stages the granulation tissue undergoes dystrophic calcification or necrosis. There is no influence on the adjacent bone. Cholesterol granuloma does not seem to be an important clinical entity. The therapy is the same as for the infectious process that is also present in the same ear.
胆固醇肉芽肿由固态代谢废物组成。其根本原因是中耳裂内存在封闭的无气腔隙，伴有黏膜增生、结缔组织黏液分泌增加及其后续机化。在这种难以消化的黏液吸收过程中会形成胆固醇晶体，进而导致小出血、纤维组织形成增加以及异物巨细胞聚集。对101份标本的分析显示，由于局部病理过程持续时间不同，胆固醇肉芽肿存在不同的组织学形式。在最终阶段，肉芽组织会发生营养不良性钙化或坏死。对相邻骨质无影响。胆固醇肉芽肿似乎并非重要的临床实体。其治疗方法与同一耳中存在的感染性病变相同。
