Energy intake and partitioning are determined by many interacting factors and their prediction is the Achilles' heel of ration formulation. Inadequate energy intake can limit milk yield and reproductive performance, whereas excessive energy intake will increase body condition, increasing the risk of health and reproductive issues in the subsequent lactation. Ration composition interacts with the physiological state of cows, making it difficult to predict DMI and the partitioning of energy accurately. However, understanding the factors controlling these allows us to devise grouping strategies and manipulate rations to optimize energy intake through lactation. Eating is controlled by the integration of signals in brain feeding centers. Ration composition affects DMI of cows via signals from ruminal distention and the hepatic oxidation of fuels. Dairy cow rations must contain a minimal concentration of relatively low-energy roughages for proper rumen function, but signals from ruminal distension can limit DMI when the drive to eat is high. Signals from the hepatic oxidation of fuels likely dominate the control of DMI in the peripartum period when cows are in a lipolytic state and later in lactation when signals from distension diminish. Therefore, the effects of the ration on DMI vary with the physiological state of the animal. Furthermore, they interact with environmental stressors such as social (e.g., overcrowding) and thermal stress. The objective of this article is to discuss the effects of ration composition on energy intake and partitioning in lactating cows and how they can be manipulated to optimize productive performance.