Gregory P, Low R B, Stirewalt W S
Department of Physiology and Biophysics, University of Vermont, College of Medicine, Burlington 05405.
Biochem J. 1987 Jul 1;245(1):133-7. doi: 10.1042/bj2450133.
The synthesis rates of different myosin isoenzymes in a single muscle, and of the same isoenzymes in different muscles (soleus, masseter and plantaris), were measured. The rate of total protein synthesis was significantly higher in the soleus [greater than 95% slow myosin (SM)] than in the plantaris [greater than 95% fast myosin (FM)]. Two fast isoenzymes, FM2 and FM3, were synthesized at different rates in the masseter, and SM was synthesized at a faster rate than FM. Intermediate myosin had a synthesis rate similar to that of FM. There was a small but significant difference between the synthesis rates of the SM isoenzymes of the soleus and masseter muscles. FM3 was synthesized faster in the masseter than in the plantaris, whereas FM2 was synthesized faster in the plantaris than in the masseter.
测量了单一肌肉中不同肌球蛋白同工酶的合成速率，以及不同肌肉（比目鱼肌、咬肌和跖肌）中相同同工酶的合成速率。比目鱼肌中总蛋白质合成速率显著高于跖肌[超过95%为慢速肌球蛋白（SM）] [超过95%为快速肌球蛋白（FM）]。两种快速同工酶FM2和FM3在咬肌中的合成速率不同，SM的合成速率比FM快。中间型肌球蛋白的合成速率与FM相似。比目鱼肌和咬肌的SM同工酶合成速率存在微小但显著的差异。FM3在咬肌中的合成速度比在跖肌中快，而FM2在跖肌中的合成速度比在咬肌中快。
