伴刀豆球蛋白A在不同气味剂浓度下对大鼠嗅觉电图的影响。
The effect of concanavalin A on the rat electro-olfactogram at various odorant concentrations.
作者信息
Shirley S G, Polak E H, Edwards D A, Wood M A, Dodd G H
机构信息
Department of Chemistry, University of Warwick, Coventry, U.K.
出版信息
Biochem J. 1987 Jul 1;245(1):185-9. doi: 10.1042/bj2450185.
We have studied the effect of concanavalin A (Con A) on the rat electro-olfactogram response to several odorants. Each odorant was applied over a range of concentrations. For hydrophobic odorants whose response was affected by Con A, the diminution in response was maximal at odorant concentrations of about 1 microM in the olfactory mucus. The (odour) concentration-dependence of the change is compatible with the idea that Con A inactivates one or more types of olfactory receptor that normally bind odorants with dissociation constants of the order of 100 nM. With hydrophilic odorants we had to apply concentrations very much higher than this to elicit any response from the system. At these high concentrations we could observe Con A-induced diminutions in response.
我们研究了伴刀豆球蛋白A（Con A）对大鼠对几种气味剂的电嗅觉图反应的影响。每种气味剂都在一定浓度范围内进行了测试。对于其反应受Con A影响的疏水性气味剂，在嗅觉黏液中气味剂浓度约为1微摩尔时，反应减弱最为明显。这种变化的（气味）浓度依赖性与以下观点相符，即Con A使一种或多种通常以约100纳摩尔解离常数结合气味剂的嗅觉受体失活。对于亲水性气味剂，我们必须施加比这高得多的浓度才能从该系统中引发任何反应。在这些高浓度下，我们可以观察到Con A诱导的反应减弱。
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