线虫秀丽隐杆线虫中特定年龄的核蛋白。
Age-specific nuclear proteins in the nematode worm Caenorhabditis elegans.
作者信息
Meheus L A, Van Beeumen J J, Coomans A V, Vanfleteren J R
机构信息
Laboratorium voor Morfologie en Systematiek der Dieren, Rijksuniversiteit Gent, Belgium.
出版信息
Biochem J. 1987 Jul 1;245(1):257-61. doi: 10.1042/bj2450257.
The nematode worm Caenorhabditis elegans is known to undergo characteristic morphological as well as physiological signs of senescence. Two-dimensional gel electrophoresis shows that alterations also occur in the pattern of the nuclear proteins as a function of age. Non-histone proteins whose level exhibits a steep fall with age are egg-specific and not involved in senescence. However, a distinct set of non-histones accumulates with age and can be considered as senescence markers. Some of these are glycoproteins, as shown by their concanavalin A-binding properties. One age-specific polypeptide, called 'protein S-28', was further characterized by peptide mapping and determination of its N-terminal amino acid sequence.
已知线虫秀丽隐杆线虫会经历衰老的特征性形态和生理迹象。二维凝胶电泳显示，随着年龄增长，核蛋白的模式也会发生变化。其水平随年龄急剧下降的非组蛋白是卵特异性的，与衰老无关。然而，一组独特的非组蛋白会随着年龄积累，可被视为衰老标志物。其中一些是糖蛋白，伴刀豆球蛋白A结合特性表明了这一点。一种年龄特异性多肽，称为“蛋白质S-28”，通过肽图谱分析和其N端氨基酸序列的测定得到了进一步表征。
Zotero 插件