针对 C3b/C4b 的治疗性药物 SB002 对实验性牙周炎炎症诱导的骨丢失的作用。
Targeting therapeutic agent against C3b/C4b, SB002, on the inflammation-induced bone loss in experimental periodontitis.
机构信息
Department of Periodontology, School of Dentistry, Tri-Service General Hospital and National Defense Medical Center, Taipei, Taiwan.
Graduate Institutes of Dental Sciences, National Defense Medical Center, Taipei, Taiwan.
出版信息
J Clin Periodontol. 2023 May;50(5):657-670. doi: 10.1111/jcpe.13772. Epub 2023 Jan 29.
AIMS
To use experimental periodontitis models in rats to investigate the correlation between local expression of the complement components C3b and C4b in periodontal tissues and disease severity, and to assess the therapeutic effects of targeting C3b/C4b on inflammatory bone loss.
MATERIALS AND METHODS
The gingival expression of C3, C3b, and C4b in animal experimental periodontitis models were analysed immunohistochemically. The therapeutic effects of the C3b/C4b inhibitor (SB002) on ligation-induced experimental periodontitis was examined using biochemical, histological, and immunohistochemical analyses.
RESULTS
The gingival expression levels of C3, C3b, and C4b were positively correlated with the severity of periodontitis. Moreover, both single and multiple injections of the C3b/C4b inhibitor had preventive and therapeutic effects on alveolar bone loss in ligation-induced experimental periodontitis with no associated adverse consequences.
CONCLUSIONS
The association between C3b/C4b and periodontitis may provide a basis for the development of novel therapeutic strategies for periodontitis and other inflammatory diseases.
目的
利用大鼠实验性牙周炎模型，探讨牙周组织中补体成分 C3b 和 C4b 的局部表达与疾病严重程度的相关性，并评估针对 C3b/C4b 的治疗效果对炎症性骨丢失的作用。
材料和方法
采用免疫组织化学方法分析动物实验性牙周炎模型中 C3、C3b 和 C4b 的牙龈表达。采用生物化学、组织学和免疫组织化学分析方法，检测 C3b/C4b 抑制剂（SB002）对结扎诱导的实验性牙周炎的治疗作用。
结果
C3、C3b 和 C4b 的牙龈表达水平与牙周炎的严重程度呈正相关。此外，C3b/C4b 抑制剂的单次和多次注射对结扎诱导的实验性牙周炎的牙槽骨丢失均具有预防和治疗作用，且无不良反应。
结论
C3b/C4b 与牙周炎之间的关联为开发牙周炎和其他炎症性疾病的新型治疗策略提供了依据。
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