State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau 999078, China.
Departments of Diagnostic Radiology, Surgery, Chemical and Biomolecular Engineering and Biomedical Engineering, Yong Loo Lin School of Medicine and Faculty of Engineering, National University of Singapore, Singapore, 119074, Singapore.
Theranostics. 2023 Jan 1;13(2):611-620. doi: 10.7150/thno.80857. eCollection 2023.
Inspired by the attractions of fruit flies to polyamines of rotten food, we developed a facile, bio-orthogonal, supramolecular homing and hunting strategy, relying on the elevated levels of polyamines in tumor as the natural guest cues to attract cucurbit [7] uril (CB[7]) functionalized liposomes to the tumor site, owing to the strong, bio-orthogonal host-guest interactions between CB[7] and polyamines. This supramolecular homing enabled a high targeting efficiency of CB[7] functionalized liposomes, and allowed better tissue penetration and retention in breast tumor. The employment of a receptor functionalized nanomedicine for direct tropism towards endogenous biomarkers as guest cues, reminiscent of natural chemotaxis but in a bio-orthogonal manner, has not been previously reported, offering new sights to the design and development of new nanoformulations that rely on bio-orthogonal interactions for chemotaxis-guided targeting.
受水果蝇对腐烂食物中多胺的吸引力的启发，我们开发了一种简便、生物正交的超分子归巢和狩猎策略，依赖于肿瘤中多胺水平的升高作为天然客体线索，吸引葫芦[7]脲（CB[7]）功能化脂质体到肿瘤部位，这是由于 CB[7]和多胺之间存在强的、生物正交的主客体相互作用。这种超分子归巢使 CB[7]功能化脂质体具有很高的靶向效率，并允许更好地穿透和保留在乳腺癌组织中。利用受体功能化的纳米药物作为内源性生物标志物的直接趋化剂作为客体线索，类似于天然趋化作用，但采用生物正交的方式，这在以前的报道中尚未出现，为设计和开发依赖生物正交相互作用的新型纳米制剂提供了新的思路，这些制剂依赖生物正交相互作用进行趋化性导向靶向。
Zotero 插件
