Zhang Liming, Svärd Antonia, Edlund Ulrica
College of Textile and Clothing, Qingdao University, Qingdao, Shandong, China.
Fibre and Polymer Technology, KTH Royal Institute of Technology, Stockholm, Sweden.
Sci Technol Adv Mater. 2023 Jan 4;24(1):2158369. doi: 10.1080/14686996.2022.2158369. eCollection 2023.
Inhomogeneous lignin from a canola (rapeseed) straw was isolated and valorized as regularly shaped spherical microparticles for drug delivery formulations. Lignin with a purity of 83% and broad molecular weight distribution (Ð > 5.0) was extracted by alkali pulping and acetylated to increase spheronization ability. Lignins with high degrees of acetylation (0.76 and 0.89) were successfully assembled into microparticles with uniform sizes (approximately 2 μm) and smooth spherical surfaces via solvent-antisolvent precipitation. Hydrophobic coumarin 153 and positively charged ciprofloxacin were used as model drugs to assess the encapsulation and release performance of lignin microparticles. Highly acetylated lignin microparticles displayed encapsulation efficiencies of 89.6% for coumarin 153% and 90.6% for ciprofloxacin. Scanning electron microscope images showed that coumarin 153 was encapsulated in the hydrophobic core, while ciprofloxacin was adsorbed on the less hydrophobic shell. The synthesis of lignin microcarriers not only provides a facile approach to utilizing waste canola straw lignin for drug delivery matrices but also has the potential to serve as an alternative lignin powder feedstock for bio-based materials.
从油菜（油菜籽）秸秆中分离出不均匀的木质素，并将其作为规则形状的球形微粒用于药物递送制剂。通过碱法制浆提取出纯度为83%且分子量分布较宽（Ð>5.0）的木质素，并进行乙酰化处理以提高其成球能力。通过溶剂-反溶剂沉淀法，成功地将高度乙酰化（乙酰化度分别为0.76和0.89）的木质素组装成尺寸均匀（约2μm）且表面光滑的球形微粒。以疏水性香豆素153和带正电荷的环丙沙星作为模型药物，评估木质素微粒的包封和释放性能。高度乙酰化的木质素微粒对香豆素153的包封效率为89.6%，对环丙沙星的包封效率为90.6%。扫描电子显微镜图像显示，香豆素153被包封在疏水核心中，而环丙沙星则吸附在疏水性较弱的壳层上。木质素微载体的合成不仅为利用废弃油菜秸秆木质素作为药物递送基质提供了一种简便方法，而且有潜力作为生物基材料的替代木质素粉末原料。
