Zhang Ziru, Feng Sheng, Almotairy Ahmed, Bandari Suresh, Repka Michael A
Department of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, University, MS 38677, United States.
Department of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, University, MS 38677, United States; Pharmaceutics and Pharmaceutical Technology Department, College of Pharmacy, Taibah University, Al Madinah AlMunawarah 30001, Saudi Arabia.
Eur J Pharm Biopharm. 2023 Feb;183:102-111. doi: 10.1016/j.ejpb.2023.01.004. Epub 2023 Jan 8.
The model of core-shell structured tablets is gaining increased interest due to its advantages in controlled-release and combinational drug delivery. Through the encapsulation of the drug by the outer shell, this model exhibits huge potential for reduced administration frequency, improved taste-masking, and personalized medication strategy. Although different types of core-shell tablets have been recently developed, most of them focused on the embedding of the solid tablets. Therefore there is still a need to investigate an optimized model in which multiple dosage forms can be loaded. This work uses hot-melt extrusion and fused deposition modeling 3D printing (FDM 3DP) techniques to develop a multifunctional core-shell model for controlled drug delivery. Acetaminophen (APAP) was used as the model drug. Hydroxypropyl cellulose (HPC) and hydroxypropyl methylcellulose (HPMC) was used as the matrix materials. Polyethylene oxide (PEO) and Eudragit RS PO (E RSPO) were used to adjust the printability while the E RSPO was expected to act as an extended-release agent due to its hydrophobicity. Liquid, semi-solid and solid dosage forms could be successfully loaded into the produced shells. The formulations were characterized by scanning electron microscopy, three point-bend tests, differential scanning calorimetry, and dissolution studies. The dissolution results suggested the modified-release character of the designed model. Overall, the designed core-shell model could be successfully produced via hot-melt extrusion paired with FDM 3DP techniques and could be utilized for the delivery of distinct dosage forms which improve the on-demand formulation development for patient-centered medication.
核壳结构片剂模型因其在控释和联合给药方面的优势而越来越受到关注。通过外壳对药物进行包封，该模型在降低给药频率、改善掩味以及个性化用药策略方面展现出巨大潜力。尽管最近已经开发出了不同类型的核壳片剂，但大多数都集中在固体片剂的包埋上。因此，仍有必要研究一种能够装载多种剂型的优化模型。这项工作采用热熔挤出和熔融沉积建模3D打印（FDM 3DP）技术来开发一种用于控释药物递送的多功能核壳模型。对乙酰氨基酚（APAP）用作模型药物。羟丙基纤维素（HPC）和羟丙基甲基纤维素（HPMC）用作基质材料。聚环氧乙烷（PEO）和丙烯酸树脂RS PO（E RSPO）用于调节可打印性，而E RSPO因其疏水性有望作为缓释剂。液体、半固体和固体剂型能够成功装载到所制备的壳中。通过扫描电子显微镜、三点弯曲试验、差示扫描量热法和溶出度研究对制剂进行了表征。溶出结果表明了所设计模型的缓释特性。总体而言，所设计的核壳模型可以通过热熔挤出与FDM 3DP技术成功制备，并可用于递送不同剂型，这有助于以患者为中心的按需制剂开发。
