Key Laboratory of Environmental Pollution and Integrative Omics, Education Department of Guangxi Zhuang Autonomous Region, Guilin Medical University, Guilin, China; School of Pharmacy, Guilin Medical University, Guilin, China.
Key Laboratory of Environmental Pollution and Integrative Omics, Education Department of Guangxi Zhuang Autonomous Region, Guilin Medical University, Guilin, China.
Gene. 2023 Mar 30;858:147191. doi: 10.1016/j.gene.2023.147191. Epub 2023 Jan 8.
The ubiquitin-proteasome system (UPS) is a major pathway for cellular protein degradation. The molecular function of the UPS is the removal of damaged proteins, and this function is applied in many biological processes, including inflammation, proliferation, and apoptosis. Accumulating evidence also suggests that the UPS also has a key role in pancreatic β-cell transdifferentiation in diabetes and can be targeted for treatment of diabetic diseases. In this review, we summarized the mechanistic roles of the UPS in the biochemical activities of pancreatic β-cells, including the role of the UPS in insulin synthesis and secretion, as well as β-cell degradation. Also, we discuss how the UPS mediates the transdifferentiation of pancreatic duct epithelial cells into β-cells as the experimental basis for the development of new strategies for the treatment of diabetes in regenerative medicine.
泛素-蛋白酶体系统（UPS）是细胞内蛋白质降解的主要途径。UPS 的分子功能是去除受损的蛋白质，这一功能应用于许多生物学过程，包括炎症、增殖和细胞凋亡。越来越多的证据还表明，UPS 在糖尿病中的胰腺β细胞转分化中也起着关键作用，并且可以作为治疗糖尿病疾病的靶点。在这篇综述中，我们总结了 UPS 在胰腺β细胞生化活性中的作用机制，包括 UPS 在胰岛素合成和分泌以及β细胞降解中的作用。此外，我们还讨论了 UPS 如何介导胰腺导管上皮细胞向β细胞的转分化，为再生医学中治疗糖尿病的新策略的发展提供实验依据。
