Li Xu-Hao, Li Jin-Ling, Dong Tian-Tian, Ma Xin, Xue Xi-Qing, Yang Ji-Guo
School of Acupuncture- Moxibustion and Tuina, 3Innovation Research Institute of TCM, Shandong University of TCM, Jinan 250355, China.
External Treatment Center of TCM, Affiliated Hospital of Shandong University of TCM.
Zhongguo Zhen Jiu. 2023 Jan 1;43(1):14-8. doi: 10.13703/j.0255-2930.20220403-0001.
To compare the therapeutic efficacy of governor vessel moxibustion combined with fluoxetine hydrochloride capsule, simple fluoxetine hydrochloride capsule and placebo moxibustion combined with fluoxetine hydrochloride capsule for mild to moderate depression with kidney- deficiency.
A total of 126 patients with mild to moderate depression with kidney- deficiency were randomized into a governor vessel moxibustion group (42 cases, 2 cases dropped off), a western medication group (42 cases, 1 case dropped off) and a placebo moxibustion group (42 cases, 1 case dropped off). The western medication group was given fluoxetine hydrochloride capsule orally, 20 mg a time, once a day. On the basis of the treatment in the western medication group, governor vessel moxibustion was applied from Dazhui (GV 14) to Yaoshu (GV 2) in the governor vessel moxibustion group, once a week; placebo moxibustion was applied in the placebo moxibustion group, once a week. Treatment of 8 weeks was required in the 3 groups. Before and after treatment, the scores of Hamilton depression scale-17 (HAMD-17), Asberg's rating scale for side effects (SERS) and TCM clinical symptom were compared, and the clinical efficacy was evaluated.
After treatment, the scores of HAMD-17, SERS and TCM clinical symptom were decreased compared before treatment in the 3 groups (<0.05), the decrease ranges of above scores in the governor vessel moxibustion group were larger than those in the western medication group and the placebo moxibustion group (<0.05). The total effective rate was 92.5% (37/40) in the governor vessel moxibustion group, which was higher than 75.6% (31/41) in the western medication group and 80.5% (33/41) in the placebo moxibustion group (<0.05).
Governor vessel moxibustion combined with fluoxetine hydrochloride capsule can improve the degree of depression and relieve the clinical symptoms in mild to moderate depression patients with kidney- deficiency, the efficacy is superior to simple fluoxetine hydrochloride capsule, and can reduce the fluoxetine hydrochloride capsule-induced adverse effect to a certain extent.
比较督脉灸联合盐酸氟西汀胶囊、单纯盐酸氟西汀胶囊、安慰剂灸联合盐酸氟西汀胶囊治疗肾虚型轻中度抑郁症的疗效。
将126例肾虚型轻中度抑郁症患者随机分为督脉灸组（42例，脱落2例）、西药组（42例，脱落1例）和安慰剂灸组（42例，脱落1例）。西药组口服盐酸氟西汀胶囊，每次20mg，每日1次。督脉灸组在西药组治疗的基础上，从大椎（GV 14）至腰俞（GV 2）进行督脉灸，每周1次；安慰剂灸组进行安慰剂灸，每周1次。3组均需治疗8周。比较治疗前后汉密尔顿抑郁量表17项（HAMD-17）评分、阿斯伯格副反应量表（SERS）评分及中医临床症状，并评价临床疗效。
治疗后，3组HAMD-17、SERS评分及中医临床症状较治疗前均降低（P<0.05），督脉灸组上述评分降低幅度大于西药组和安慰剂灸组（P<0.05）。督脉灸组总有效率为92.5%（37/40），高于西药组的75.6%（31/41）和安慰剂灸组的80.5%（33/41）（P<0.05）。
督脉灸联合盐酸氟西汀胶囊可改善肾虚型轻中度抑郁症患者的抑郁程度，缓解临床症状，疗效优于单纯盐酸氟西汀胶囊，并能在一定程度上减轻盐酸氟西汀胶囊所致不良反应。
