Dusseault Sonya K, Okobi Okelue Edwards, Thakral Nimish, Sankar Vignesh, Gunawardene Ishan, Dawkins Bryan, Abu Yaw, Davis Barry
Family Medicine, Lakeside Medical Center, Belle Glade, Florida, USA.
Internal medicine, Memorial Healthcare Systems, Pembroke Pines, Florida, USA.
Case Rep Gastroenterol. 2022 Nov 8;16(3):588-594. doi: 10.1159/000523935. eCollection 2022 Sep-Dec.
Primary Peritoneal Mesothelioma is a rapidly aggressive and rare neoplasm that arises from the lining of mesothelial cells of the peritoneum and spreads extensively within the confines of the abdominal cavity. The pathogenesis of all forms of mesothelioma is strongly associated with industrial pollutants, of which asbestos is the principal carcinogen. Characteristically, asbestos exposure has a strong relationship with mesothelioma of the pleura, but the peritoneal cavity is the second most commonly affected site. Additionally, in contrast to pleural mesothelioma, which has a male predominance (male-female ratio of between four and five to one), women comprise approximately one-half of all cases of malignant peritoneal mesothelioma. A thorough history of occupational/paraoccupational exposure along with histopathology is the key to timely diagnosis and treatment.
原发性腹膜间皮瘤是一种侵袭性迅速且罕见的肿瘤，起源于腹膜间皮细胞衬里，并在腹腔范围内广泛扩散。所有形式的间皮瘤的发病机制都与工业污染物密切相关，其中石棉是主要致癌物。典型的是，接触石棉与胸膜间皮瘤有很强的关联，但腹腔是第二常见的受累部位。此外，与以男性为主（男女比例为四到五比一）的胸膜间皮瘤不同，女性约占所有恶性腹膜间皮瘤病例的一半。详细的职业/准职业接触史以及组织病理学是及时诊断和治疗的关键。
