Erin A N, Davitashvili N G, Prilipko L L, Boldyrev A A, Lushchak V I
Biokhimiia. 1987 Jul;52(7):1180-5.
The effect of alkyl resorcin isolated from the cells of Azotobacter chroococcum and of its structural analog devoid of the alkyl chain (resorcin) on liver microsomes and brain synaptosomes of the rat as well as on rabbit skeletal muscle sarcoplasmic reticulum fragments during activation of lipid peroxidation was studied. Alkyl resorcin was shown to produce a much more potent antioxidant effect as compared with resorcin, since it inhibited lipid peroxidation in all the three types of membranes under study at much lower concentrations. Both alkyl resorcin and resorcin which inhibit lipid peroxidation prevented lipid peroxidation-induced structural-functional damages of synaptosomal and sarcoplasmic reticulum fragment membranes. Unlike resorcin, alkyl resorcin exerted an additional effect on brain synaptosomal membranes which consisted in the stabilization of barrier functions of membranes during incomplete inhibition of lipid peroxidation. The cumulative data suggest that stabilization necessitates the presence of both resorcin radical and alkyl chain in the alkyl resorcin molecule.
研究了从褐球固氮菌细胞中分离出的烷基间苯二酚及其不含烷基链的结构类似物（间苯二酚）在脂质过氧化激活过程中对大鼠肝脏微粒体和脑突触体以及兔骨骼肌肌质网片段的影响。结果表明，与间苯二酚相比，烷基间苯二酚具有更强的抗氧化作用，因为它在低得多的浓度下就能抑制所研究的三种类型膜中的脂质过氧化。抑制脂质过氧化的烷基间苯二酚和间苯二酚都能防止脂质过氧化诱导的突触体和肌质网片段膜的结构功能损伤。与间苯二酚不同，烷基间苯二酚对脑突触体膜有额外作用，即在脂质过氧化未完全抑制时稳定膜的屏障功能。累积数据表明，这种稳定作用需要烷基间苯二酚分子中同时存在间苯二酚自由基和烷基链。
