酚类脂质的生物活性。
Biological activity of phenolic lipids.
机构信息
Department of Lipids and Liposomes, University of Wroclaw, Poland.
出版信息
Cell Mol Life Sci. 2010 Mar;67(6):841-60. doi: 10.1007/s00018-009-0193-1.
Abstract
Phenolic lipids are a very diversified group of compounds derived from mono and dihydroxyphenols, i.e., phenol, catechol, resorcinol, and hydroquinone. Due to their strong amphiphilic character, these compounds can incorporate into erythrocytes and liposomal membranes. In this review, the antioxidant, antigenotoxic, and cytostatic activities of resorcinolic and other phenolic lipids are described. The ability of these compounds to inhibit bacterial, fungal, protozoan and parasite growth seems to depend on their interaction with proteins and/or on their membrane-disturbing properties.
摘要
酚类脂是一组非常多样化的化合物，来源于单羟基酚和二羟基酚，即苯酚、儿茶酚、间苯二酚和对苯二酚。由于其强两亲性，这些化合物可以掺入到红细胞和脂质体膜中。在这篇综述中，描述了间苯二酚和其他酚类脂的抗氧化、抗原毒性和细胞抑制活性。这些化合物抑制细菌、真菌、原生动物和寄生虫生长的能力似乎取决于它们与蛋白质的相互作用和/或它们的膜干扰特性。
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