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Minimizing mosaicism: assessing the impact of fertilization method on rate of mosaicism after next-generation sequencing (NGS) preimplantation genetic testing for aneuploidy (PGT-A).最大限度地减少嵌合体:评估胚胎植入前遗传学检测(PGT-A)中下一代测序(NGS)后不同受精方法对嵌合体发生率的影响。
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Preimplantation genetic testing for aneuploidy in poor ovarian responders with four or fewer oocytes retrieved.对卵巢反应不良患者(取卵数为 4 个或更少)进行胚胎植入前染色体非整倍体检测。
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引用本文的文献

1
PGT-A for low responders: an authors' response.针对低反应者的胚胎植入前基因检测-非整倍体筛查:作者回应
J Assist Reprod Genet. 2023 Mar;40(3):693-694. doi: 10.1007/s10815-023-02742-x. Epub 2023 Feb 7.

本文引用的文献

1
What to advise to patients with only one good quality blastocyst, PGT-A or not? Outcomes of 2064 cycles.对于只有一个优质囊胚的患者,建议进行 PGT-A 检测吗?2064 个周期的结果。
J Assist Reprod Genet. 2022 Nov;39(11):2555-2562. doi: 10.1007/s10815-022-02617-7. Epub 2022 Sep 20.
2
Embryo attrition in planned PGT-A: predicting the number of available blastocysts for transfer.胚胎损耗在 PGT-A 中的作用:预测可用于移植的囊胚数量。
J Assist Reprod Genet. 2022 Jan;39(1):173-181. doi: 10.1007/s10815-021-02365-0. Epub 2022 Jan 3.
3
Preimplantation genetic testing for aneuploidy in poor ovarian responders with four or fewer oocytes retrieved.对卵巢反应不良患者(取卵数为 4 个或更少)进行胚胎植入前染色体非整倍体检测。
J Assist Reprod Genet. 2020 May;37(5):1147-1154. doi: 10.1007/s10815-020-01765-y. Epub 2020 Apr 13.
4
Attitudes toward preimplantation genetic testing for aneuploidy among patients with recurrent pregnancy loss in Japan.日本复发性流产患者对胚胎植入前染色体非整倍体检测的态度。
J Obstet Gynaecol Res. 2020 Apr;46(4):567-574. doi: 10.1111/jog.14212. Epub 2020 Feb 7.
5
The dilemma of aneuploidy screening on low responders.低反应者非整倍体筛查的困境。
Curr Opin Obstet Gynecol. 2018 Jun;30(3):179-184. doi: 10.1097/GCO.0000000000000449.

一个优质胚胎该如何处理,我们应该重点关注哪里?

What to do with one good quality blastocyst and where do we place the emphasis?

机构信息

Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Brigham & Women's Hospital, Boston, MA, USA.

出版信息

J Assist Reprod Genet. 2023 Mar;40(3):689-690. doi: 10.1007/s10815-023-02712-3. Epub 2023 Jan 13.

DOI:10.1007/s10815-023-02712-3
PMID:36637585
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10033777/
Abstract

The use of preimplantation genetic testing for aneuploidy (PGT-A) in poor responders undergoing assisted reproductive technology has been a topic of debate with controversial results. It is critical to note the denominators used in data presented. Herein, we comment on the results found in the study by Kahraman et al. on the utility of PGT-A in poor responders with a single, good-quality blastocyst.

摘要

利用胚胎植入前遗传学检测(PGT-A)对接受辅助生殖技术的反应不良者进行非整倍体检测一直是一个有争议的话题。需要注意的是,所呈现的数据使用的分母。在此,我们对 Kahraman 等人关于在单个优质囊胚的反应不良者中使用 PGT-A 的效用的研究结果进行评论。