Jiangxi University of Chinese Medicine, Nanchang 330004, China.
2 Department of acupuncture and moxibustion, the Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang 330006, China.
J Tradit Chin Med. 2023 Feb;43(1):175-180. doi: 10.19852/j.cnki.jtcm.20221006.002.
We want to explore the analgesic brain effect of the moxibustion at heat-sensitized Yaoyangguan (GV3) in patients with lumbar disc herniation (LDH) and myofascial pain syndrome (MPS). In an assessor-blinded observational study, we will include 15 LDH and 15 MPS. They will accept same treatment of heat-sensitive moxibustion at Yaoyangguan (GV3). The resting-state functionality magnetic resonance imaging image data of brain activities before and after treatment will be analyzed by mean fractional amplitude of low-frequency fluctuation, regional homogeneity analysis and brain functional connection. We select seed of first sensory cortex, second sensory cortex, insula cortex, periaqueductal gray and anterior cingulate cortex as the regions of interest to analyse the relationship between brain functional connectivity of pain-related networks and clinical data. Our study could disclose key brain targets and central response characteristics of the analgesic brain effect and the brain functional connection of heat-sensitive moxibustion.
我们希望探索艾灸热敏穴（腰阳关穴，GV3）对腰椎间盘突出症（LDH）和肌筋膜疼痛综合征（MPS）患者镇痛脑效应。在一项评估者设盲的观察性研究中，我们将纳入 15 例 LDH 和 15 例 MPS 患者。他们将接受相同的热敏灸腰阳关穴（GV3）治疗。治疗前后脑活动的静息态功能磁共振成像数据将通过低频振幅分数、局部一致性分析和脑功能连接进行分析。我们选择初级感觉皮层、次级感觉皮层、脑岛皮层、导水管周围灰质和前扣带皮层作为感兴趣区，分析痛觉相关网络的脑功能连接与临床数据之间的关系。我们的研究可以揭示热敏灸镇痛脑效应的关键脑靶点和中枢反应特征，以及热敏灸的脑功能连接。
