自身抗原导向治疗免疫检查点抑制剂介导心肌炎的潜力。
The potential of auto-antigen-guided treatment of immune checkpoint inhibitor-mediated myocarditis.
机构信息
Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA; Stanford University School of Medicine, Stanford, CA, USA.
Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA.
出版信息
Med. 2023 Jan 13;4(1):13-14. doi: 10.1016/j.medj.2022.12.005.
Immune checkpoint inhibitor (ICI)-mediated myocarditis is a rare but devastating side effect of cancer immunotherapy with up to 40% mortality and long-term cardiac issues such as arrhythmias and heart failure in affected patients. Recently, Axelrod et al. suggested an auto-antigen-driven mechanism as the immunological basis for this disease.
免疫检查点抑制剂（ICI）介导的心肌炎是癌症免疫治疗的一种罕见但严重的副作用，高达 40%的死亡率和长期的心脏问题，如心律失常和心力衰竭在受影响的患者。最近，Axelrod 等人提出了一种自身抗原驱动的机制作为这种疾病的免疫学基础。
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