血小板激动剂对气道反应性和胸腔内血小板聚集的影响。
Effect of platelet agonists on airway reactivity and intrathoracic platelet accumulation.
作者信息
Robertson D N, Page C P
机构信息
Department of Pharmacology, King's College, London University, Chelsea Campus.
出版信息
Br J Pharmacol. 1987 Sep;92(1):105-11. doi: 10.1111/j.1476-5381.1987.tb11301.x.
Abstract
1 Intravenous infusion of platelet activating factor (Paf), adenosine diphosphate (ADP), collagen and the thromboxane-mimetic U46619 induced a dose-related accumulation of 111indium-labelled platelets into the thoracic region of anaesthetized guinea-pigs. 2 Intravenous infusion of Paf increased the reactivity of the airways to the spasmogen histamine. Such changes were not observed following treatment with ADP, collagen or U46619. 3 Paf-induced bronchial hyperreactivity is not secondary to pulmonary platelet recruitment, changes in basal lung function or cardiovascular changes. 4 Paf-induced bronchial hyperreactivity is not dependent upon the endogenous generation of ADP or thromboxane.
摘要
静脉输注血小板活化因子（Paf）、二磷酸腺苷（ADP）、胶原蛋白以及血栓素类似物U46619可使麻醉的豚鼠胸部区域出现与剂量相关的铟-111标记血小板积聚。
静脉输注Paf可增加气道对致痉剂组胺的反应性。用ADP、胶原蛋白或U46619治疗后未观察到此类变化。
Paf诱导的支气管高反应性并非继发于肺血小板募集、基础肺功能变化或心血管变化。
Paf诱导的支气管高反应性不依赖于ADP或血栓素的内源性生成。
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