口腔扁平苔藓和寻常型天疱疮中调节性T细胞潜在的相互出现：一项荟萃分析。
A potential reciprocal emergence of regulatory T cells in oral lichen planus and pemphigus vulgaris: A meta-analysis.
作者信息
Liu Wei, Zhang Qianqian, Bao Zhexuan, Shen Xuemin
机构信息
Department of Stomatology, Fengcheng Hospital of Fengxian District, Shanghai Ninth People's Hospital Fengcheng Branch Hospital, Shanghai, China.
College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai, China.
出版信息
J Dent Sci. 2023 Jan;18(1):437-442. doi: 10.1016/j.jds.2022.07.009. Epub 2022 Jul 30.
Oral lichen planus (OLP) and pemphigus vulgaris (PV) are 2 common inflammatory mucocutaneous diseases of immune-based etiology. Evidence indicates regulatory T (Treg) cells maybe play a role in the pathogenesis of OLP and PV, which are caused by aberrant immune responses. In this report, 7 eligible case-control studies containing 517 OLP patients and 261 healthy controls (HC) were identified. The level of Tregs was significantly higher in OLP patients than HC (mean difference: 1.79; 95%CI: 0.99, 2.60). On the other hand, 7 eligible case-control studies containing 169 PV patients and 121 HC were identified. Conversely, the level of Tregs was significantly lower in PV patients than HC (mean difference: -2.49; 95%CI: -3.90, -1.08). Collectively, this analysis for the first time reported reciprocal emergence of Tregs in OLP and PV using meta-analysis, and provided an interesting insight into a previously undescribed the linkage of the 2 mucocutaneous diseases.
口腔扁平苔藓（OLP）和寻常型天疱疮（PV）是两种常见的基于免疫病因的炎症性黏膜皮肤疾病。有证据表明，调节性T（Treg）细胞可能在OLP和PV的发病机制中起作用，这两种疾病是由异常免疫反应引起的。在本报告中，确定了7项符合条件的病例对照研究，其中包括517例OLP患者和261例健康对照（HC）。OLP患者的Tregs水平显著高于HC（平均差异：1.79；95%CI：0.99，2.60）。另一方面，确定了7项符合条件的病例对照研究，其中包括169例PV患者和121例HC。相反，PV患者的Tregs水平显著低于HC（平均差异：-2.49；95%CI：-3.90，-1.08）。总体而言，该分析首次使用荟萃分析报告了OLP和PV中Tregs的相互出现情况，并为这两种黏膜皮肤疾病以前未描述的联系提供了有趣的见解。
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