Bruns Nora, Schara-Schmidt Ulrike, Dohna-Schwake Christian
Zentrum für Kinder- und Jugendmedizin, Klinik für Kinderheilkunde I (Neonatologie, Pädiatrische Intensivmedizin, Neuropädiatrie), Universitätsklinikum Essen, Hufelandstr. 55, 45147, Essen, Deutschland.
Center for Translational and Behavioral Sciences (TNBS), Universitätsklinikum Essen, Hufelandstr. 55, 45147, Essen, Deutschland.
Nervenarzt. 2023 Feb;94(2):75-83. doi: 10.1007/s00115-022-01424-w. Epub 2023 Jan 16.
Pediatric neurocritical care requires multidisciplinary expertise for the care of critically ill children. Approximately 14-16% of critically ill children in pediatric intensive care suffer from a primary neurological disease, whereby cardiac arrest and severe traumatic brain injury play major roles in Europe. The short-term goal of interventions in the pediatric intensive care unit is to stabilize vital functions, whereas the overarching goal is to achieve survival without neurological damage that enables fulfillment of the individual developmental physiological potential. For this reason, evidence-based methods for brain monitoring during the acute phase and recovery are necessary, which can be performed clinically or with technical devices. This applies to critically ill children with primary neurological diseases and for all children at risk for secondary neurological insults. Patients with diseases of the peripheral nervous system are also treated in pediatric intensive care medicine. In these patients, the primary aim frequently consists of bridging the time until recovery after acute deterioration, for example during an infection. In these patients, monitoring the cerebral function can be especially challenging, because due to the underlying disease the results of the examination cannot be interpreted in the same way as for previously neurologically healthy children. This article summarizes the complexity of pediatric neurocritical care by presenting examples of diagnostic and therapeutic approaches in the context of various neurological diseases that can be routinely encountered in the pediatric intensive care unit and can only be successfully treated by multidisciplinary teams.
儿科神经重症监护需要多学科专业知识来照顾危重症儿童。在儿科重症监护病房中,约14% - 16%的危重症儿童患有原发性神经系统疾病,在欧洲,心脏骤停和严重创伤性脑损伤是主要病因。儿科重症监护病房干预措施的短期目标是稳定生命功能,而总体目标是实现存活且无神经损伤,以确保个体发育生理潜能得以实现。因此,急性期和康复期基于证据的脑监测方法很有必要,可通过临床手段或技术设备来进行。这适用于患有原发性神经系统疾病的危重症儿童以及所有有继发性神经损伤风险的儿童。患有周围神经系统疾病的患者也在儿科重症监护医学中接受治疗。在这些患者中,主要目标通常是度过急性恶化后的恢复阶段,例如在感染期间。在这些患者中,监测脑功能可能特别具有挑战性,因为由于基础疾病,检查结果的解读方式与之前神经系统健康的儿童不同。本文通过介绍在儿科重症监护病房中经常遇到的各种神经系统疾病背景下的诊断和治疗方法示例,总结了儿科神经重症监护的复杂性,这些疾病只有通过多学科团队才能成功治疗。