Luo Chenmin, Liu Shengyang, Luo Wei, Wang Jing, He Hongyan, Chen Can, Xiao Lan, Liu Changsheng, Li Yulin
Engineering Research Center for Biomedical Materials of Ministry of Education, Key Laboratory for Ultrafine Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, School of Material Science & Engineering, East China University of Science and Technology, Shanghai, 200237, China.
Wenzhou Institute of Shanghai University, Wenzhou, 325000, China.
Macromol Biosci. 2023 Apr;23(4):e2200507. doi: 10.1002/mabi.202200507. Epub 2023 Feb 5.
Biodegradable materials are pivotal in the biomedical field, where how to precisely control their structure and performance is critical for their translational application. In this study, poly(L-lactide-b-ε-caprolactone) block copolymers (bPLCL) with well-defined segment structure are obtained by a first synthesis of poly(ε-caprolactone) soft block, followed by ring opening polymerization of lactide to form poly(L-lactide acid) hard block. The pre-polymerization allows for fabrication of bPLCL with the definite compositions of soft/hard segment while preserving the individual segment of their special soft or hard segment. These priorities make the bPLCL afford biodegradable polymer with better mechanical and biodegradable controllability than the random poly(L-lactide-co-ε-caprolactone) (rPLCL) synthesized via traditional one-pot polymerization. 10 mol% ε-caprolactone introduction can result in a formation of an elastic polymer with elongation at break of 286.15% ± 55.23%. Also, bPLCL preserves the unique crystalline structure of the soft and hard segments to present a more sustainable biodegradability than the rPLCL. The combinative merits make the pre-polymerization technique a promising strategy for a scalable production of PLCL materials for potential biomedical application.
可生物降解材料在生物医学领域至关重要，在该领域中，如何精确控制其结构和性能对于它们的转化应用至关重要。在本研究中，通过首先合成聚（ε-己内酯）软段，然后进行丙交酯的开环聚合以形成聚（L-乳酸）硬段，获得了具有明确链段结构的聚（L-丙交酯-b-ε-己内酯）嵌段共聚物（bPLCL）。预聚合允许制备具有确定软/硬链段组成的bPLCL，同时保留其特殊软段或硬段的各个链段。这些优势使得bPLCL比通过传统一锅法聚合合成的无规聚（L-丙交酯-co-ε-己内酯）（rPLCL）具有更好的机械性能和生物降解可控性的可生物降解聚合物。引入10 mol%的ε-己内酯可形成一种弹性聚合物，其断裂伸长率为286.15%±55.23%。此外，bPLCL保留了软段和硬段独特的晶体结构，比rPLCL具有更可持续的生物降解性。这些综合优点使得预聚合技术成为一种有前景的策略，可用于大规模生产用于潜在生物医学应用的PLCL材料。
