Silver K H, Buczek J A, Esser P D, Nichols A B
College of Physicians and Surgeons, Columbia University, New York, New York.
Cathet Cardiovasc Diagn. 1987 Sep-Oct;13(5):291-300. doi: 10.1002/ccd.1810130502.
A rapid microprocessor technique for measuring the cross-sectional area, diameter, and relative percentage stenosis of coronary atherosclerotic lesions by cinevideodensitometric analysis was developed and validated. Video images of projected 35-mm coronary arteriographic cine frames were analyzed from cinevideodensitometric profile curves recorded for the catheter shaft, normal artery, and stenotic segment. In radiographic phantom studies of calibrated, contrast-filled, plexiglass cylinders, cinevideodensitometric measurements correlated linearly with percentage relative stenosis (r = 0.98; SEE = 4.1%), diameter (r = 0.99; SEE = 0.12 mm), and cross-sectional area (r = 0.99; SEE = 0.32 mm2). In postmortem studies of two patients dying after coronary arteriography, cross-sectional areas of arterial segments measured by cinevideodensitometry correlated well (r = 0.99; SEE = 0.71 mm) with areas of acrylic resin casts of the coronary arteries. Intraobserver variability (r = 0.99; SEE = 2.6%) and interobserver variability (r = 0.96; SEE = 5.3%) of cinevideodensitometric measurements of coronary arteriograms were low. Additionally, percentage relative stenosis measured in the right anterior oblique projection correlated well with measurements in the left anterior oblique projection (r = 0.98; SEE = 0.11 mm2) of patients with eccentric stenotic lesions. Lastly, cinevideodensitometric measurements were significantly (p less than 0.05) more reproducible than caliper measurements. This inexpensive dedicated microprocessor system provides rapid cinevideodensitometric measurements of coronary arterial dimensions, without requiring manual tracing of arterial segments or the major expense of a main-frame computer system.
开发并验证了一种通过电影视频密度分析测量冠状动脉粥样硬化病变横截面积、直径和相对狭窄百分比的快速微处理器技术。从记录导管轴、正常动脉和狭窄段的电影视频密度轮廓曲线中分析35毫米冠状动脉造影电影帧的视频图像。在校准的、充满造影剂的有机玻璃圆柱体的放射摄影模型研究中，电影视频密度测量与相对狭窄百分比（r = 0.98；标准误 = 4.1%）、直径（r = 0.99；标准误 = 0.12毫米）和横截面积（r = 0.99；标准误 = 0.32平方毫米）呈线性相关。在两名冠状动脉造影术后死亡患者的尸检研究中，通过电影视频密度测量的动脉段横截面积与冠状动脉丙烯酸树脂铸型的面积相关性良好（r = 0.99；标准误 = 0.71毫米）。冠状动脉造影电影视频密度测量的观察者内变异性（r = 0.99；标准误 = 2.6%）和观察者间变异性（r = 0.96；标准误 = 5.3%）较低。此外，在右前斜位投影中测量的相对狭窄百分比与偏心狭窄病变患者左前斜位投影中的测量值相关性良好（r = 0.98；标准误 = 0.11平方毫米）。最后，电影视频密度测量比卡尺测量具有显著更高的可重复性（p小于0.05）。这种价格低廉的专用微处理器系统可快速进行冠状动脉尺寸的电影视频密度测量，无需手动描绘动脉段或使用大型计算机系统的高昂费用。
