Department of Ultrasound, Guanghua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 200052, China.
Department of Ultrasound, First Hospital of Shanxi Medical University, Taiyuan, 030001, Shanxi, China.
BMC Cardiovasc Disord. 2023 Jan 16;23(1):22. doi: 10.1186/s12872-022-03035-4.
The new non-invasive arterial stiffness indices, arterial pressure volume index (API) is explored as a novel marker of residual stress in the wall of the peripheral muscular arteries at zero-stress state in clinical settings. The present study aimed to study the association of API with cardiovascular disease (CVD) risk in China (China-PAR).
According to China-PAR score, participants were divided into three groups: low risk (< 5%), medium risk (5-9.9%), and high risk (≥ 10.0%). API ≥ 31 was defined as high API, and the incidences of high API were compared. Logistic regression models were used to analyze the risk factors of high API and high risk China-PAR categories. The association between China-PAR and API was analyzed by restrictive cubic spline.
The study included 4311 participants. After adjustments for confounding factors, high API was independent factor associated with high risk China-PAR categories, and the probability of high API was 1.366 times higher than that in normal API subjects. While, the independent factors associated with high API were BMI, blood pressure and heart rate. Furthermore, API had a significant U-shaped association with China-PAR. CVD risk was lowest with API of 19 units, the fastest increase at 26 units and the flattest starting point at 59 units.
API, an indicator of arterial stiffness and residual stress, had a U-shaped association with China-PAR score and might play an important role in predicting CVD risk in Chinese natural populations.
新的无创动脉僵硬度指数，动脉压力容积指数（API）被探索作为一种新的标记物，用于在零压力状态下评估外周肌性动脉壁的残余应力，这在临床环境中具有重要意义。本研究旨在探讨 API 与中国人群心血管疾病（CVD）风险（China-PAR）的相关性。
根据 China-PAR 评分，将参与者分为三组：低危组（<5%）、中危组（5-9.9%）和高危组（≥10.0%）。API≥31 定义为高 API，比较高 API 的发生率。采用 Logistic 回归模型分析高 API 和高风险 China-PAR 类别的危险因素。采用限制性立方样条分析 China-PAR 与 API 的相关性。
本研究共纳入 4311 名参与者。在调整混杂因素后，高 API 是与高危 China-PAR 类别的独立相关因素，高 API 受试者发生高风险 China-PAR 类别的概率是正常 API 受试者的 1.366 倍。而与高 API 相关的独立因素是 BMI、血压和心率。此外，API 与 China-PAR 呈显著 U 型关系。当 API 为 19 单位时，CVD 风险最低，当 API 为 26 单位时，风险增加最快，当 API 为 59 单位时，风险增加最平缓。
API 是动脉僵硬度和残余应力的指标，与 China-PAR 评分呈 U 型关系，可能在预测中国自然人群 CVD 风险方面发挥重要作用。
