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戒烟可降低心力衰竭风险:一项全国性队列研究

Smoking Cessation Reduces the Risk of Heart Failure: A Nationwide Cohort Study.

作者信息

Yoo Jung Eun, Jeong Su-Min, Yeo Yohwan, Jung Wonyoung, Yoo Juhwan, Han Kyungdo, Lee Cheol Min, Park Jin Ho, Park Kyung Woo, Shin Dong Wook

机构信息

Department of Family Medicine, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul, Republic of Korea.

Department of Family Medicine, Supportive Care Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

出版信息

JACC Heart Fail. 2023 Mar;11(3):277-287. doi: 10.1016/j.jchf.2022.07.006. Epub 2022 Sep 7.

Abstract

BACKGROUND

There is a lack of data for the incidence of heart failure (HF) according to changes in smoking behaviors.

OBJECTIVES

The authors aimed to investigate the effects of smoking behavior change on development of HF.

METHODS

In this population-based, retrospective cohort study using the Korean National Health Insurance System database, the authors identified 778,608 current smokers who participated in a health screening program in 2009 and in a follow-up screening in 2011. Participants were categorized into quitters, reducers I (≥50% reduction) and II (<50% reduction), sustainers, and increasers.

RESULTS

During a median follow-up of 6.3 years, there were 23,329 HF events (4.8 per 1,000 person-years). Compared with sustainers, the risk of HF was increased among increasers (adjusted hazard ratio [aHR]: 1.06 [95% CI: 1.02-1.10]). By contrast, quitters had a reduced risk for HF (aHR: 0.86 [95% CI: 0.83-0.90]). Even heavy smokers who quit smoking had a lower risk for HF than those who sustained heavy smoking (aHR: 0.90 [95% CI: 0.85-0.95]). In reducers, the risk of HF was not reduced but rather increased slightly (≥50% reduction, aHR: 1.06 [95% CI: 1.01-1.11]; <50% reduction, aHR: 1.04 [95% CI: 1.00-1.08]).

CONCLUSIONS

Current smokers who increased their smoking amount were associated with a higher risk for HF development compared to sustainers, whereas self-reported smoking cessation was associated with a lower risk of HF. There was no benefit from reduction in smoking amount. Self-reported smoking cessation should be reinforced whenever possible to prevent HF.

摘要

背景

关于根据吸烟行为变化得出的心力衰竭(HF)发病率的数据匮乏。

目的

作者旨在研究吸烟行为改变对HF发生发展的影响。

方法

在这项基于人群的回顾性队列研究中,作者利用韩国国民健康保险系统数据库,确定了778,608名在2009年参加健康筛查项目并于2011年参加后续筛查的当前吸烟者。参与者被分为戒烟者、减量者I(减少≥50%)、减量者II(减少<50%)、持续吸烟者和增量者。

结果

在中位随访6.3年期间,发生了23,329例HF事件(每1000人年4.8例)。与持续吸烟者相比,增量者发生HF的风险增加(调整后风险比[aHR]:1.06[95%置信区间:1.02 - 1.10])。相比之下,戒烟者发生HF的风险降低(aHR:0.86[95%置信区间:0.83 - 0.90])。即使是戒烟的重度吸烟者发生HF的风险也低于持续重度吸烟者(aHR:0.90[95%置信区间:0.85 - 0.95])。在减量者中,HF风险并未降低,反而略有增加(减少≥50%,aHR:1.06[95%置信区间:1.01 - 1.11];减少<50%,aHR:1.04[95%置信区间:1.00 - 1.08])。

结论

与持续吸烟者相比,吸烟量增加的当前吸烟者发生HF的风险更高,而自我报告的戒烟与较低的HF风险相关。减少吸烟量并无益处。应尽可能加强自我报告的戒烟措施以预防HF。

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