Palaparthi Elizabeth Caroline, K Priyanka, Ignasimuthu Arockiamary, N Gaoudam, Sade Nagasaikaran, Bade Naveen, Jakka Bharath Kumar, Gogineni Khyathi Krishna, Dunde Anjaneyulu, Medabala Tambi, Periasamy Panneerselvam
Department of Internal Medicine, Shasta Regional Medical Center - Prime Healthcare, Redding, USA.
Department of Obstetrics and Gynecology, Vinayaka Mission's Kirupananda Variyar Medical College and Hospitals, Vinayaka Mission's Research Foundation (Deemed to be University), Salem, IND.
Cureus. 2025 Apr 1;17(4):e81570. doi: 10.7759/cureus.81570. eCollection 2025 Apr.
Heart failure (HF) remains a leading cause of morbidity and mortality worldwide. While pharmacological therapy is foundational, lifestyle modifications are increasingly recognised for their complementary role. This narrative review explores the synergistic effects of lifestyle interventions, combined with pharmacological treatment, in HF management. A literature search (2000-2025) was conducted using PubMed, Scopus, Cochrane, and Google Scholar, to identify studies on integrative approaches to HF care. Lifestyle changes, such as dietary modification, exercise, weight management, smoking and alcohol cessation, and psychosocial support, enhance the efficacy of standard therapies, improve quality of life, and reduce hospitalisations. Integration with medications, like renin-angiotensin-aldosterone system (RAAS) inhibitors, beta-blockers, and sodium-glucose cotransporter-2 (SGLT2) inhibitors, shows improved neurohormonal balance, reduced inflammation, better endothelial function, and delayed cardiac remodelling. However, socioeconomic and cultural barriers challenge real-world implementation. Combining lifestyle interventions with pharmacotherapy provides a holistic, patient-centred strategy for HF management. Future efforts should focus on personalised care, multidisciplinary teams, and policy support, to improve adherence and outcomes.
心力衰竭（HF）仍然是全球发病和死亡的主要原因。虽然药物治疗是基础，但生活方式的改变因其互补作用而越来越受到认可。这篇叙述性综述探讨了生活方式干预与药物治疗相结合在心力衰竭管理中的协同作用。使用PubMed、Scopus、Cochrane和谷歌学术进行了文献检索（2000 - 2025年），以确定关于心力衰竭综合护理方法的研究。饮食调整、运动、体重管理、戒烟限酒和心理社会支持等生活方式的改变可提高标准治疗的疗效，改善生活质量并减少住院次数。与肾素 - 血管紧张素 - 醛固酮系统（RAAS）抑制剂、β受体阻滞剂和钠 - 葡萄糖协同转运蛋白2（SGLT2）抑制剂等药物联合使用，可改善神经激素平衡、减轻炎症、改善内皮功能并延缓心脏重塑。然而，社会经济和文化障碍对实际应用构成挑战。将生活方式干预与药物治疗相结合为心力衰竭管理提供了一种以患者为中心的整体策略。未来的努力应集中在个性化护理、多学科团队和政策支持上，以提高依从性和改善治疗结果。
