Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur (UNS), Bahía Blanca, Argentina.
Planta Piloto de Ingeniería Química (PLAPIQUI), UNS-CONICET, Bahía Blanca, Argentina.
Pharm Dev Technol. 2023 Jan;28(1):143-151. doi: 10.1080/10837450.2023.2169455. Epub 2023 Jan 30.
Chewable gels present significant advantages over conventional dosage forms, despite their development is not comprehensively assessed. In this sense, six formulations, varying gelatine concentration, dose, and form of incorporation of praziquantel, were developed and characterized. The novelty of this approach focused not only on the development of the formulation itself but also on the incorporation of the drug in a nanoparticulated form. The obtained results for moisture content, water activity, pH, and drug content were within the expected values for this type of formulation. On the other hand, texture and disintegration parameters were influenced by the form of incorporation of praziquantel and the amount of gelatine added. Finally, dissolution of chewable gels showed significant differences with intermediate products, though the improved dissolution of the nanoparticulated drug was maintained. In conclusion, nanoparticulate drugs can be incorporated into these semisolid formulations and could be successfully applied to other low-aqueous solubility drugs.
咀嚼凝胶制剂相对于传统剂型具有显著优势，尽管其开发尚未得到全面评估。在这种情况下，我们开发并表征了 6 种不同明胶浓度、剂量和吡喹酮添加形式的凝胶制剂。该方法的新颖之处不仅在于制剂本身的开发，还在于将药物以纳米颗粒形式添加。所获得的水分含量、水分活度、pH 值和药物含量均在这种类型制剂的预期值范围内。另一方面，质地和崩解参数受到吡喹酮添加形式和添加明胶量的影响。最后，咀嚼凝胶的溶出度与中间产品有显著差异，但纳米颗粒药物的溶出度得到了改善。总之，纳米颗粒药物可以被纳入这些半固体制剂中，并可能成功应用于其他低水溶性药物。
