卤化物钙钛矿/硫化铅异质结用于检测碱性磷酸酶（ALP）的光电化学性能增强。

A halide perovskite/lead sulfide heterostructure with enhanced photoelectrochemical performance for the sensing of alkaline phosphatase (ALP).

机构信息

Hunan Provincial Key Laboratory of Micro & Nano Materials Interface Science, College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan Province, 410083, P. R. China.

National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Central South University, Changsha, Hunan Province, 410083, P. R. China.

出版信息

Chem Commun (Camb). 2023 Jan 31;59(10):1361-1364. doi: 10.1039/d2cc06142b.

DOI:10.1039/d2cc06142b

PMID:36649093

Abstract

For the construction of halide perovskite-based photoelectrochemical (PEC) biosensors in aqueous solution, the balance between retaining the excellent photoelectric performances of the halide perovskite and the protective modification of the halide perovskite has always been a challenging problem. In this work, a simple and sensitive photoelectrochemical biosensor based on inorganic halide perovskite CsPbBr as the photoactive material for the detection of alkaline phosphatase (ALP) was reported. The substrate sodium thiophosphate (NaSPO) can be catalyzed by ALP to produce hydrogen sulfide (HS), which can react with the lead site on the surface of the CsPbBr film to form lead sulfide (PbS), resulting in a stable heterostructure and enhanced photocurrent intensity. The possible mechanism of enhanced photocurrent response of CsPbBr/PbS heterojunctions was studied in detail. This work paves a new way for applying halide perovskites in different biosensor designs.

摘要

为了在水溶液中构建基于卤化物钙钛矿的光电化学（PEC）生物传感器，始终存在着在保持卤化物钙钛矿优异光电性能和卤化物钙钛矿的保护修饰之间取得平衡的挑战。在这项工作中，报道了一种基于无机卤化物钙钛矿 CsPbBr 的简单而灵敏的光电化学生物传感器，用于检测碱性磷酸酶（ALP）。碱性磷酸酶（ALP）可以催化底物硫代磷酸钠（NaSPO）产生硫化氢（HS），HS 可以与 CsPbBr 薄膜表面的铅位点反应，形成硫化铅（PbS），从而形成稳定的异质结构并增强光电流强度。详细研究了 CsPbBr/PbS 异质结增强光电流响应的可能机制。这项工作为在不同的生物传感器设计中应用卤化物钙钛矿开辟了新途径。