用于构建烯胺基磺酰氟的()-2-甲氧基乙烯-1-磺酰氟的发现。
Discovery of ()-2-Methoxyethene-1-sulfonyl Fluoride for the Construction of Enaminyl Sulfonyl Fluoride.
作者信息
Liu Min, Tang Wenjian, Qin Hua-Li
机构信息
School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan 430070, China.
School of Pharmacy, Anhui Medical University, Hefei 230032, China.
出版信息
J Org Chem. 2023 Feb 3;88(3):1909-1917. doi: 10.1021/acs.joc.2c02836. Epub 2023 Jan 17.
PMID:36649643
Abstract
A new sulfonyl fluoride reagent ()-2-methoxyethene-1-sulfonyl fluoride (MeO-ESF) was developed and successfully applied for the construction of enaminyl sulfonyl fluoride (-ESF). This protocol provides highly atom-economical access to diverse -ESF and produces CHOH as the sole byproduct under mild and environmentally benign conditions.
摘要
一种新型磺酰氟试剂（）-2-甲氧基乙烯-1-磺酰氟（MeO-ESF）被开发出来，并成功应用于烯胺基磺酰氟（-ESF）的构建。该方法以高原子经济性合成了多种-ESF，并在温和且环境友好的条件下仅产生CHOH作为副产物。
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