Wang Si-Jie, Zhao Min-Yan, Zhao Peng-Cheng, Zhang Wen, Rao Guo-Wu
College of Pharmaceutical Science, Institute of Drug Development & Chemical Biology, Zhejiang University of Technology, Hangzhou 310014, P.R. China.
Curr Med Chem. 2024;31(4):410-452. doi: 10.2174/0929867330666230117160632.
According to the 2017 ILAE's official definition, epilepsy is a slow brain disease state characterized by recurrent episodes. Due to information released by ILAE in 2017, it can be divided into four types, including focal epilepsy, generalized epilepsy, combined generalized, and focal epilepsy, and unknown epilepsy. Since 1989, 24 new antiepileptic drugs have been approved to treat different types of epilepsy. Besides, there are a variety of antiepileptic medications under clinical monitoring. These novel antiepileptic drugs have plenty of advantages. Over the past 33 years, there have been many antiepileptic drugs on the mearket, but no one has been found that can completely cure epilepsy. In this paper, the mentioned drugs were classified according to their targets, and the essential information, and clinical studies of each drug were described. The structure-activity relationship of different chemical structures was summarized. This paper provides help for the follow-up research on epilepsy drugs.
根据国际抗癫痫联盟（ILAE）2017年的官方定义，癫痫是一种以反复发作为特征的慢性脑部疾病状态。根据ILAE在2017年发布的信息，它可分为四种类型，包括局灶性癫痫、全身性癫痫、全身性与局灶性癫痫综合征合并型以及不明类型癫痫。自1989年以来，已有24种新型抗癫痫药物被批准用于治疗不同类型的癫痫。此外，还有多种抗癫痫药物正在临床监测中。这些新型抗癫痫药物有诸多优点。在过去的33年里，市场上出现了许多抗癫痫药物，但尚未发现一种能完全治愈癫痫的药物。本文根据这些药物的作用靶点对其进行分类，并描述了每种药物的基本信息和临床研究情况。总结了不同化学结构的构效关系。本文为癫痫药物的后续研究提供了帮助。
