Stead R J, Hodson M E, Batten J C, Adams J, Jacobs H S
Department of Cystic Fibrosis, Brompton Hospital, London, UK.
Clin Endocrinol (Oxf). 1987 Feb;26(2):187-95. doi: 10.1111/j.1365-2265.1987.tb00776.x.
Menstrual history in relation to nutritional status and lung function was assessed in 45 adolescent and adult patients with cystic fibrosis (CF). Twenty patients had regular menstrual cycles (of whom six had been pregnant), 12 had primary or secondary amenorrhoea, 11 had irregular cycles and two were premenarcheal. Patients with regular menstruation had a significantly higher body mass index and percentage body fat (estimated from skinfold thickness measurements) than those with amenorrhoea (P less than 0.001), and also better lung function (P less than 0.01). A linear discriminant analysis indicated that of the four indices studied percentage body fat was the most important predictor of menstrual function. Ovarian and uterine morphology were studied by ultrasonography in 28 patients and 17 healthy controls. In 10 patients multicystic ovaries were noted. Even in patients with regular cycles uterine size was reduced (P less than 0.01) and in those with amenorrhoea appeared to be related to thinness. Amenorrhoea in CF is an appropriate adaptive response in preventing pregnancy, but the resultant oestrogen deficiency and psychological effects must be considered.
对45例青少年及成年囊性纤维化（CF）患者的月经史与营养状况及肺功能之间的关系进行了评估。20例患者月经周期规律（其中6例曾怀孕），12例有原发性或继发性闭经，11例月经周期不规律，2例处于月经初潮前。月经规律的患者体重指数及体脂百分比（通过皮褶厚度测量估算）显著高于闭经患者（P<0.001），肺功能也更好（P<0.01）。线性判别分析表明，在所研究的四个指标中，体脂百分比是月经功能最重要的预测指标。对28例患者及17名健康对照者进行了超声检查以研究卵巢和子宫形态。10例患者发现有多囊卵巢。即使月经周期规律的患者子宫大小也减小（P<0.01），闭经患者的子宫大小似乎与消瘦有关。CF患者的闭经是预防怀孕的一种适应性反应，但由此导致的雌激素缺乏及心理影响必须予以考虑。
