Galioto G B, Mevio E, Benazzo M, Arizzi L, Scelsi M
Ent Clinic, University of Pavia, Italy.
Clin Otolaryngol Allied Sci. 1987 Aug;12(4):303-8. doi: 10.1111/j.1365-2273.1987.tb00206.x.
The authors present a series of 130 patients with laryngeal tumours submitted to total or horizontal laryngectomy and to neck dissection. The possible correlations between the staging and histology of the primary lesion, tumour marker (LASA) and the incidence of lymph node metastases are examined. The information provided by clinical and histopathological parameters is no doubt useful, but the margin of clinical error is high. On the contrary, the tumour marker concentration (LASA) was significantly higher in the patients whose lymph nodes were found to be histologically invaded, than in those without metastatic spread. Consequently, the LASA test may assume clinical importance before surgical therapy and in the follow-up of treated patients.
作者报告了130例接受全喉或水平喉切除术及颈部清扫术的喉肿瘤患者。研究了原发灶的分期和组织学、肿瘤标志物（LASA）与淋巴结转移发生率之间的可能相关性。临床和组织病理学参数提供的信息无疑是有用的，但临床误差范围很大。相反，组织学检查发现淋巴结受侵的患者，其肿瘤标志物浓度（LASA）明显高于无转移扩散的患者。因此，LASA检测在手术治疗前及治疗后患者的随访中可能具有临床重要性。
