Brew B J, O'Sullivan D J, Darveniza P, Selby G, Fryer J, Evans W
Department of Neurology, St Vincent's Hospital, Sydney, New South Wales.
Clin Exp Neurol. 1987;23:119-26.
Neoplastic angioendotheliosis is a rare disease in which malignant cells are found within numerous blood vessels throughout the body in the absence of any detectable extravascular primary malignancy. The disorder has a propensity for clinical neurological involvement despite pathological evidence of systemic spread. To date 23 patients with neurological involvement have been described. This report adds a further 3 cases. There was no definite evidence to support the theory that the malignancy arises in endothelial cells; no primary extravascular tumour was found. At present a definite conclusion about the cause of the disease cannot be made.
肿瘤性血管内皮细胞增生症是一种罕见疾病，在全身众多血管内发现恶性细胞，而未发现任何可检测到的血管外原发性恶性肿瘤。尽管有全身扩散的病理证据，但该疾病倾向于临床累及神经系统。迄今为止，已有23例累及神经系统的患者被报道。本报告又增加了3例。没有明确证据支持恶性肿瘤起源于内皮细胞的理论；未发现原发性血管外肿瘤。目前，关于该疾病的病因无法得出明确结论。
