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人芽囊原虫:人类致病性及甲硝唑治疗有效性的证据

Blastocystis hominis: evidence for human pathogenicity and effectiveness of metronidazole therapy.

作者信息

Guirges S Y, Al-Waili N S

机构信息

Private Clinic, Al-Mashtel, New Baghdad, Iraq.

出版信息

Clin Exp Pharmacol Physiol. 1987 Apr;14(4):333-5. doi: 10.1111/j.1440-1681.1987.tb00979.x.

DOI:10.1111/j.1440-1681.1987.tb00979.x
PMID:3665198
Abstract
  1. Clinical symptoms and oral treatment with metronidazole were studied in 103 patients with pure infections by Blastocystis hominis. 2. The results showed that excessive flatulence is the chief gastrointestinal symptom associated occasionally with diarrhoea and abdominal cramps. All the patients showed good responses with treatment of metronidazole and 74 patients whose stools were reexamined 1-2 months after the treatment demonstrated no signs of infections. 3. It is concluded that B. hominis is a pathogenic intestinal parasite and the infection could be eradicated successfully by oral metronidazole.
摘要
  1. 对103例单纯人芽囊原虫感染患者的临床症状及甲硝唑口服治疗进行了研究。2. 结果显示,胃肠胀气过多是主要的胃肠道症状,偶尔伴有腹泻和腹部绞痛。所有患者甲硝唑治疗反应良好,74例患者在治疗后1 - 2个月复查粪便未显示感染迹象。3. 得出结论:人芽囊原虫是一种致病性肠道寄生虫,口服甲硝唑可成功根除感染。

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引用本文的文献

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A Systematic Review about the Efficacy of Antiparasitic Agents in the Treatment of Blastocystis Species.关于抗寄生虫药物治疗芽囊原虫疗效的系统评价
Acta Parasitol. 2025 Nov 10;70(6):208. doi: 10.1007/s11686-025-01145-5.
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Molecular epidemiology of blastocystosis in Malaysia: does seasonal variation play an important role in determining the distribution and risk factors of Blastocystis subtype infections in the Aboriginal community?马来西亚芽囊原虫病的分子流行病学:季节变化在确定原住民社区芽囊原虫亚型感染的分布和危险因素方面是否起重要作用?
Parasit Vectors. 2017 Jul 31;10(1):360. doi: 10.1186/s13071-017-2294-2.
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Evaluation of cellular retinoic acid binding protein 2 gene expression through the retinoic acid pathway by co-incubation of Blastocystis ST-1 with HT29 cells in vitro.
通过体外将人芽囊原虫ST-1与HT29细胞共孵育,评估视黄酸途径中细胞视黄酸结合蛋白2基因的表达。
Parasitol Res. 2016 May;115(5):1965-75. doi: 10.1007/s00436-016-4939-z. Epub 2016 Feb 25.
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New insights on classification, identification, and clinical relevance of Blastocystis spp.关于芽囊原虫属的分类、鉴定及临床相关性的新见解
Clin Microbiol Rev. 2008 Oct;21(4):639-65. doi: 10.1128/CMR.00022-08.
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Blastocystis hominis revisited.人芽囊原虫再探讨。
Clin Microbiol Rev. 1996 Oct;9(4):563-84. doi: 10.1128/CMR.9.4.563.
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Epidemiology and pathogenicity of Blastocystis hominis.人芽囊原虫的流行病学与致病性
J Clin Microbiol. 1990 Jan;28(1):116-21. doi: 10.1128/jcm.28.1.116-121.1990.
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Blastocystis hominis.人芽囊原虫
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Blastocystis hominis--past and future.人芽囊原虫——过去与未来
Clin Microbiol Rev. 1991 Jan;4(1):61-79. doi: 10.1128/CMR.4.1.61.